Hampson NB, Corman JM, et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, In.... Date of publication 2007 Sep 1;volume 34(5):329-34.
1. Undersea Hyperb Med. 2007 Sep-Oct;34(5):329-34.
Rate of delivery of hyperbaric oxygen treatments does not affect response in soft
tissue radionecrosis.
Hampson NB(1), Corman JM.
Author information:
(1)Center for Hyperbaric Medicine, Section of Pulmonary and Critical Care
Medicine, Virginia Mason Medical Center Seattle, Washington, USA.
BACKGROUND: Soft tissue radiation necrosis (STRN) is effectively treated with
hyperbaric oxygen (HBO,), believed to result from stimulation ofangiogenesis in
radiation-injured tissue. Thirty to forty HBO2 treatments are usually recommended
for STRN. For various reasons, different hyperbaric facilities offer these
treatments once or twice daily and from 5-7 days weekly. It is not known whether
the clinical response differs as a result of the rate of administration of HBO2
treatments.
METHODS: Details of hyperbaric treatment courses of patients treated for
radiation enteritis/proctitis (n = 65) and cystitis (n = 94) at a single
institution were reviewed. Outcomes were compared with the total number of HBO2
treatments administered and also rate of treatment administration.
RESULTS: Responses were similar for both forms of STRN whether the patient
averaged fewer or greater than 5 treatments per week, or even < or = 3 versus >
or = 7 treatments weekly. Outcome did differ, however, dependant on the total
number of treatments administered. Response was better in patients receiving 30
or more total treatments, as compared with fewer.
CONCLUSIONS: Soft tissue radionecrosis of the gastrointestinal tract or bladder
is (1) effectively treated with hyperbaric oxygen, (2) has a higher response rate
if at least 30 treatments are administered, and (3) is equally responsive to
rates of hyperbaric treatment ranging from 3 or fewer to 7 or more treatments per
week.
PMID: 18019083 [Indexed for MEDLINE]
