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Miller GE, Seale J, et al.
Lymphology. Date of publication 1981 Dec 1;volume 14(4):161-6.
1. Lymphology. 1981 Dec;14(4):161-6. Lymphatic clearance during compressive loading. Miller GE, Seale J. Lymphatic clearance of radioactive sulfur colloid is measured as a function of externally applied pressure on the hind limb of mongrel dogs. A dead weight device is placed over the site of subcutaneous injection. A solid state Si (Li) is placed into a slot at the bottom of the device to continuously record activity of the tracer. An exponential decrease in activity is modeled as a dual decay resulting from both tracer half life decay and lymphatic clearance of the tagged sulfur colloid. External pressure is seen to enhance lymph clearance until a critical closing pressure is reached, whereupon the vessel collapses and lymph flow is drastically reduced. A closing pressure of 60 mmHg is observed for several experiments. Lymph flow per tissue volume is seen to rise from a mean of 0.324 ml/hr/ml for uncompressed tissue to 0.96 ml/hr/ml for fully enhanced flow in other experiments at 60 mmHg. Results at a pressure of 75 mmHg show almost no lymph clearance suggesting complete vessel closure. PMID: 7334832 [Indexed for MEDLINE]
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Pressure Ulcers/Injuries - Introduction and Assessment