WoundReference improves clinical decisions
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Sheehan P, Jones P, Giurini JM, Caselli A, Veves A, et al.
Plastic and reconstructive surgery. Date of publication 2006 Jun 1;volume 117(7 Suppl):239S-244S.
1. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):239S-244S. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Sheehan P(1), Jones P, Giurini JM, Caselli A, Veves A. Author information: (1)Diabetes Foot and Ankle Center, Hospital for Joint Diseases Orthopaedic Institute, New York University School of Medicine, New York, NY, USA. Republished from Diabetes Care. 2003 Jun;26(6):1879-82. OBJECTIVE: To assess the ability of the 4-week healing rate to predict complete healing over a 12-week period in a large prospective multicenter trial of diabetic patients with foot ulceration. RESEARCH DESIGN AND METHODS: We examined the change in ulcer area over a 4-week period as a predictor of wound healing within 12 weeks in patients who were seen weekly in a prospective, randomized controlled trial. RESULTS: Wound area measurements at baseline and after 4 weeks were performed in 203 patients. The midpoint between the percentage area reduction from baseline at 4 weeks in patients healed versus those not healed at 12 weeks was found to be 53%. Subjects with a reduction in ulcer area greater than the 4-week median had a 12-week healing rate of 58%, whereas those with reduction in ulcer area less than the 4-week median had a healing rate of only 9% (P < 0.01). The absolute change in ulcer area at 4 weeks was significantly greater in healers versus nonhealers (1.5 versus 0.8 cm2, P < 0.02). The percent change in wound area at 4 weeks in those who healed was 82% (95% CI 70-94), whereas in those who failed to heal, the percent change in wound area was 25% (15-35; P < 0.001). CONCLUSIONS: The percent change in foot ulcer area after 4 weeks of observation is a robust predictor of healing at 12 weeks. This simple tool may serve as a pivotal clinical decision point in the care of diabetic foot ulcers for early identification of patients who may not respond to standard care and may need additional treatment. DOI: 10.1097/01.prs.0000222891.74489.33 PMID: 16799391
Appears in following Topics:
Diabetic Foot Ulcer - Hyperbaric Oxygen Therapy