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Dixit S, Baganizi DR, Sahu R, Dosunmu E, Chaudhari A, Vig K, Pillai SR, Singh SR, Dennis VA, et al.
Journal of biological engineering. Date of publication 2017 Dec 13;volume 11():49.
1. J Biol Eng. 2017 Dec 13;11:49. doi: 10.1186/s13036-017-0089-9. eCollection 2017. Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin. Dixit S(#)(1)(2), Baganizi DR(#)(1), Sahu R(#)(1), Dosunmu E(1), Chaudhari A(1), Vig K(1), Pillai SR(1), Singh SR(1), Dennis VA(1). Author information: (1)Center for Nanobiotechnology Research and Department of Biological Sciences, Alabama State University, 1627 Harris Way, Montgomery, AL 36104 USA. (2)Immunity, Inflammation, and Disease Laboratory, NIH/NIEHS, Durham, 27709 NC USA. (#)Contributed equally The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting given that in most situations autografts cannot be used. The emergence of artificial skin substitutes provides alternative treatment with the capacity to reduce the dependency on the increasing demand of cadaver skin grafts. Over the years, considerable research efforts have focused on strategies for skin repair or permanent skin graft transplantations. Available skin substitutes include pre- or post-transplantation treatments of donor cells, stem cell-based therapies, and skin equivalents composed of bio-engineered acellular or cellular skin substitutes. However, skin substitutes are still prone to immunological rejection, and as such, there is currently no skin substitute available to overcome this phenomenon. This review focuses on the mechanisms of skin rejection and tolerance induction and outlines in detail current available strategies and alternatives that may allow achieving full-thickness skin replacement and repair. DOI: 10.1186/s13036-017-0089-9 PMCID: PMC5729423 PMID: 29255480 Conflict of interest statement: Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Cellular and/or Tissue Based Products