Dixit S, Baganizi DR, Sahu R, Dosunmu E, Chaudhari A, Vig K, Pillai SR, Singh SR, Dennis VA, et al.
Journal of biological engineering. Date of publication 2017 Dec 13;volume 11():49.
1. J Biol Eng. 2017 Dec 13;11:49. doi: 10.1186/s13036-017-0089-9. eCollection 2017.
Immunological challenges associated with artificial skin grafts: available
solutions and stem cells in future design of synthetic skin.
Dixit S(#)(1)(2), Baganizi DR(#)(1), Sahu R(#)(1), Dosunmu E(1), Chaudhari A(1),
Vig K(1), Pillai SR(1), Singh SR(1), Dennis VA(1).
Author information:
(1)Center for Nanobiotechnology Research and Department of Biological Sciences,
Alabama State University, 1627 Harris Way, Montgomery, AL 36104 USA.
(2)Immunity, Inflammation, and Disease Laboratory, NIH/NIEHS, Durham, 27709 NC
USA.
(#)Contributed equally
The repair or replacement of damaged skins is still an important, challenging
public health problem. Immune acceptance and long-term survival of skin grafts
represent the major problem to overcome in grafting given that in most situations
autografts cannot be used. The emergence of artificial skin substitutes provides
alternative treatment with the capacity to reduce the dependency on the
increasing demand of cadaver skin grafts. Over the years, considerable research
efforts have focused on strategies for skin repair or permanent skin graft
transplantations. Available skin substitutes include pre- or post-transplantation
treatments of donor cells, stem cell-based therapies, and skin equivalents
composed of bio-engineered acellular or cellular skin substitutes. However, skin
substitutes are still prone to immunological rejection, and as such, there is
currently no skin substitute available to overcome this phenomenon. This review
focuses on the mechanisms of skin rejection and tolerance induction and outlines
in detail current available strategies and alternatives that may allow achieving
full-thickness skin replacement and repair.
DOI: 10.1186/s13036-017-0089-9
PMCID: PMC5729423
PMID: 29255480
Conflict of interest statement: Not applicable.Not applicable.The authors declare
that they have no competing interests.Springer Nature remains neutral with regard
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