WoundReference improves clinical decisions
 Choose the role that best describes you
Li Y, Gao Y, Gao Y, Chen D, Wang C, Liu G, Yang X, Ran X, et al.
Journal of diabetes. Date of publication 2018 Sep 5;volume ():.
1. J Diabetes. 2018 Sep 5. doi: 10.1111/1753-0407.12850. [Epub ahead of print] Autologous platelet-rich gel treatment for diabetic chronic cutaneous ulcers: A meta-analysis of randomized controlled trials. Li Y(1), Gao Y(1), Gao Y(1), Chen D(1), Wang C(1), Liu G(2), Yang X(3), Ran X(1). Author information: (1)Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China. (2)Chinese Cochrane Centre, Chengdu, China. (3)Institute of Business Analytics, University of Alabama, Tuscaloosa, Alabama. BACKGROUND: In recent years, many studies have reported that autologous platelet-rich gel (APG) is an effective adjuvant treatment for chronic cutaneous ulcers in diabetics. The aim of this study was to explore the efficacy and safety of APG for the topical treatment of diabetic chronic cutaneous ulcers. METHODS: The China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Chinese Wanfang database, PubMed, EMBASE, EBSCOhost, and Cochrane Library were systematically searched for relevant studies published up to 18 October 2017. Fixed- and random-effects models were used to calculate risk ratios (RR), odds ratios (ORs), and mean difference (MD) with 95% confidence intervals (95% CI). Subgroup analyses were conducted according to the Diabetic Foot Wagner Classification. RESULTS: Fifteen randomized control trials (RCTs) with 829 patients were eligible for inclusion in this analysis. Compared with standard care or conventional treatment, APG significantly improved the healing rate (RR 1.39; 95% CI 1.29, 1.50; P < 0.00001), shortened the healing time (MD -9.18; 95% CI -11.32, -7.05; P < 0.00001), and reduced the incidence of infection (OR 0.34; 95% CI 0.15, 0.77; P = 0.009). CONCLUSIONS: Current evidence suggests that APG is effective and safe, and is feasible for use as an adjuvant treatment for diabetic ulcers, especially chronic refractory ulcers. However, more RCTs with a good design and of a high quality are needed before the use of APG can be implemented widely. © 2018 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. DOI: 10.1111/1753-0407.12850 PMID: 30182534
Appears in following Topics:
Diabetic Foot Ulcer - Treatment