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Hirase T, Ruff E, Surani S, Ratnani I, et al.
World journal of diabetes. Date of publication 2018 Oct 15;volume 9(10):172-179.
1. World J Diabetes. 2018 Oct 15;9(10):172-179. doi: 10.4239/wjd.v9.i10.172. Topical application of platelet-rich plasma for diabetic foot ulcers: A systematic review. Hirase T(1), Ruff E(2), Surani S(3), Ratnani I(4). Author information: (1)Department of Orthopaedic Surgery, Houston Methodist Hospital, Houston, TX 77030, United States. (2)Department of Plastic and Reconstructive Surgery, University of Texas Medical Branch, Galveston, TX 77555, United States. (3)Department of Medicine, Pulmonary, Critical Care and Sleep Medicine, Texas A and M University, Corpus Christi, TX 77807, United States. srsurani@hotmail.com. (4)Department of Anesthesiology and Critical Care, Houston Methodist Hospital, Houston, TX 77030, United States. AIM: To determine if topical application of platelet-rich plasma (PRP) to diabetic foot ulcers (DFUs) results in superior healing rates. METHODS: A systematic review was registered with PROSPERO and performed using PRISMA guidelines. Level I-IV investigations of topical PRP application in DFUs were sought in multiple databases including: MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials. The search terms used were "platelet rich plasma", "diabetes", "ulcers", and "wound". The Modified Coleman Methodology Score (MCMS) was used to analyze study methodological quality. Study heterogeneity and a mostly non-comparative nature of evidence precluded meta-analysis. Only the outcome measurements used by more than 50% of the studies were included in the data synthesis to increase power of the measurement over that of individual studies. A weighted mean of healing rate per week between PRP group vs controls were compared using two-sample z-tests using P-value of less than 0.05 for significance. RESULTS: One thousand two hundred and seventeen articles were screened. Eleven articles (322 PRP subjects, 126 controls, PRP subject mean age 58.4 ± 7.2 years, control mean age 58.7 ± 5.9 years) were analyzed. Six articles were level II evidence, four were level III, and one article was level IV. The mean MCMS was 61.8 ± 7.3. Healing rate was significantly faster with PRP application compared to controls (0.68 ± 0.56 cm2/wk vs 0.39 ± 0.09 cm2/wk; P < 0.001). Mean heal time to > 90% of the original ulcer area was 7.8 ± 2.7 wk and 8.3 ± 3.7 wk for patients in the PRP group and control groups, respectively (P = 0.115). There were significantly lower adverse effects reported with PRP application compared to controls (7 wound infections, 1 contact dermatitis vs 14 wound infections, 1 maceration; P < 0.001). CONCLUSION: The topical application of PRP for DFUs results in statistically superior healing rates and lower complication rates compared to controls. DOI: 10.4239/wjd.v9.i10.172 PMCID: PMC6198285 PMID: 30364787 Conflict of interest statement: Conflict-of-interest statement: All the authors declare that they have no competing interests.
Appears in following Topics:
Diabetic Foot Ulcer - Treatment