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Shu X, Shu S, Tang S, Yang L, Liu D, Li K, Dong Z, Ma Z, Zhu Z, Din J, et al.
Endocrine journal. Date of publication 2018 Apr 26;volume 65(4):403-413.
1. Endocr J. 2018 Apr 26;65(4):403-413. doi: 10.1507/endocrj.EJ17-0424. Epub 2018 Jan 22. Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis. Shu X(1), Shu S(1), Tang S(1), Yang L(2), Liu D(1), Li K(1), Dong Z(1), Ma Z(3), Zhu Z(1), Din J(1). Author information: (1)Department of Burn and Plastic Surgery, 2nd Affiliated Hospital of Shantou University Medical College, Shantou 515041, China. (2)Translational Medicine Center, 2nd Affiliated Hospital of Shantou University Medical College, Shantou 515041, China. (3)Department of Orthopaedics, Jinxiang Hospital Affiliated to Jining Medical College, Shandong 272200, China. Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. However, consensus has not been reached. To assess the current evidence regarding the efficiency and potential advantages of stem cell-based therapy compared with conventional standard treatment and/or placebo in the treatment of diabetic foot ulcer. A comprehensive search in PubMed, EmBase, Cochrane Central and Web of Science databases was conducted during December 2016 and a systematic review and meta-analysis of all relevant studies were performed. A total of 7 studies that involved 224 diabetic foot patients, classified as Wagner grades 1-5, were analyzed. The pooled results confirmed the benefits of using the stem cell treatment. Partial and/or complete healing were significantly higher in the stem cell group compared with the control group (77.4% vs. 31.9%; RR: 2.22; 95% CI, 1.65-2.98). Subgroup analysis on ABI and TCP02 also confirmed the results. The present meta-analysis indicates that stem cell-based therapy can enhance the healing of diabetic foot ulcers and is associated with lesser pain, lower amputation rate and improved prognosis compared with normal treatment. Well-designed randomized controlled trials are required in the future in order to confirm and update these findings. DOI: 10.1507/endocrj.EJ17-0424 PMID: 29353870 [Indexed for MEDLINE]
Appears in following Topics:
Diabetic Foot Ulcer - Treatment