Shu X, Shu S, Tang S, Yang L, Liu D, Li K, Dong Z, Ma Z, Zhu Z, Din J, et al.
Endocrine journal. Date of publication 2018 Apr 26;volume 65(4):403-413.
1. Endocr J. 2018 Apr 26;65(4):403-413. doi: 10.1507/endocrj.EJ17-0424. Epub 2018
Jan 22.
Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a
meta-analysis.
Shu X(1), Shu S(1), Tang S(1), Yang L(2), Liu D(1), Li K(1), Dong Z(1), Ma Z(3),
Zhu Z(1), Din J(1).
Author information:
(1)Department of Burn and Plastic Surgery, 2nd Affiliated Hospital of Shantou
University Medical College, Shantou 515041, China.
(2)Translational Medicine Center, 2nd Affiliated Hospital of Shantou University
Medical College, Shantou 515041, China.
(3)Department of Orthopaedics, Jinxiang Hospital Affiliated to Jining Medical
College, Shandong 272200, China.
Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic
patient. Its treatment often requires multidisciplinary joint efforts, diverse
strategies have been adopted to address this annoying issue, including stem
cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc.
However, consensus has not been reached. To assess the current evidence regarding
the efficiency and potential advantages of stem cell-based therapy compared with
conventional standard treatment and/or placebo in the treatment of diabetic foot
ulcer. A comprehensive search in PubMed, EmBase, Cochrane Central and Web of
Science databases was conducted during December 2016 and a systematic review and
meta-analysis of all relevant studies were performed. A total of 7 studies that
involved 224 diabetic foot patients, classified as Wagner grades 1-5, were
analyzed. The pooled results confirmed the benefits of using the stem cell
treatment. Partial and/or complete healing were significantly higher in the stem
cell group compared with the control group (77.4% vs. 31.9%; RR: 2.22; 95% CI,
1.65-2.98). Subgroup analysis on ABI and TCP02 also confirmed the results. The
present meta-analysis indicates that stem cell-based therapy can enhance the
healing of diabetic foot ulcers and is associated with lesser pain, lower
amputation rate and improved prognosis compared with normal treatment.
Well-designed randomized controlled trials are required in the future in order to
confirm and update these findings.
DOI: 10.1507/endocrj.EJ17-0424
PMID: 29353870 [Indexed for MEDLINE]
