Campitiello F, Mancone M, Della Corte A, Guerniero R, Canonico S, et al.
Updates in surgery. Date of publication 2017 Dec 1;volume 69(4):523-529.
1. Updates Surg. 2017 Dec;69(4):523-529. doi: 10.1007/s13304-017-0461-9. Epub 2017
May 11.
To evaluate the efficacy of an acellular Flowable matrix in comparison with a wet
dressing for the treatment of patients with diabetic foot ulcers: a randomized
clinical trial.
Campitiello F(1), Mancone M(2), Della Corte A(1), Guerniero R(1), Canonico S(1).
Author information:
(1)Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences,
University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples,
Italy.
(2)Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences,
University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples,
Italy. manfredi.mancone@alice.it.
The authors aimed to evaluate the efficacy of an advanced wound matrix (Integra
Flowable Wound Matrix, Integra LifeScience Corp, Plainsboro, NJ, USA) for
treating wounds with irregular geometries versus a wet dressing in patients with
diabetic foot ulcers. Sixty patients with diabetic foot ulcers (Grades 3 Wagner)
were included in this randomized clinical trial. The study was conducted in the
General Surgery Unit and Geriatric of the Second University of Naples, Italy, in
the last 12 months. Forty-six cases of diabetic foot ulcers were equally and
randomly divided into control and test groups. The first group treated with
Integra Flowable Wound Matrix, while the control group with a wet dressing. Both
groups were evaluated once a week for 6 weeks to value the degree of
epithelialization and granulation tissue of the wound. The complete healing rate
in the whole study population was 69.56% (Integra Flowable Wound Matrix group,
86.95%, control group, 52.17%; p = 0.001). Amputation and rehospitalization rates
were higher in the control group compared to the first group, therefore, the
difference was statistically significant (p = 0.0019; p = 0.028, respectively).
The Integra Flowable Wound Matrix, was significantly superior, compared to the
wet dressing, by promoting the complete healing of diabetic foot ulcers. Ease of
use, absence of adverse effects, and a facilitated wound healing process are
among the properties of the matrix. These characteristics make it appropriate in
the management of diabetic foot ulcers. Additional research will shed more light
on the promising advantages of this material in healing diabetic foot ulcers.
DOI: 10.1007/s13304-017-0461-9
PMID: 28497218 [Indexed for MEDLINE]
