Barret JP, Dziewulski P, Ramzy PI, Wolf SE, Desai MH, Herndon DN, et al.
Plastic and reconstructive surgery. Date of publication 2000 Jan 1;volume 105(1):62-5.
1. Plast Reconstr Surg. 2000 Jan;105(1):62-5.
Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns.
Barret JP(1), Dziewulski P, Ramzy PI, Wolf SE, Desai MH, Herndon DN.
Author information:
(1)Shriners Burns Hospital and the University of Texas Medical Branch, Galveston,
USA. j.p.barret.nerin@chir.azg.nl
Partial-thickness burns in children have been treated for many years by daily,
painful tubbing, washing, and cleansing of the burn wound, followed by topical
application of antimicrobial creams. Pain and impaired wound healing are the main
problems. We hypothesized that the treatment of second-degree burns with Biobrane
is superior to topical treatment. Twenty pediatric patients were prospectively
randomized in two groups to compare the efficacy of Biobrane versus 1% silver
sulfadiazine. The rest of the routine clinical protocols were followed in both
groups. Demographic data, wound healing time, length of hospital stay, pain
assessments and pain medication requirements, and infection were analyzed and
compared. Main outcome measures included pain, pain medication requirements,
wound healing time, length of hospital stay, and infection. The application of
Biobrane to partial-thickness burns proved to be superior to the topical
treatment. Patients included in the biosynthetic temporary cover group presented
with less pain and required less pain medication. Length of hospital stay and
wound healing time were also significantly shorter in the Biobrane group. None of
the patients in either group presented with wound infection or needed skin
autografting. In conclusion, the treatment of partial-thickness burns with
Biobrane is superior to topical therapy with 1% silver sulfadiazine. Pain, pain
medication requirements, wound healing time, and length of hospital stay are
significantly reduced.
PMID: 10626971 [Indexed for MEDLINE]
