Lázaro-Martínez JL, García-Morales E, Beneit-Montesinos JV, Martínez-de-Jesús FR, Aragón-Sánchez FJ, et al.
Cirugia espanola. Date of publication 2007 Jul 1;volume 82(1):27-31.
1. Cir Esp. 2007 Jul;82(1):27-31.
[Randomized comparative trial of a collagen/oxidized regenerated cellulose
dressing in the treatment of neuropathic diabetic foot ulcers].
[Article in Spanish]
Lázaro-Martínez JL(1), García-Morales E, Beneit-Montesinos JV, Martínez-de-Jesús
FR, Aragón-Sánchez FJ.
Author information:
(1)Unidad de Pie Diabético, Clínica Universitaria de Podología, Universidad
Complutense de Madrid, Madrid, Spain. diabetes@enf.ucm.es
INTRODUCTION: Diabetic foot is a complication of diabetes mellitus that manifests
with the development of ulcers that frequently precede amputation. Several
studies have verified that the environment of the diabetic neuropathic foot ulcer
contains a high concentration of metalloproteinases. The aim of the present study
was to evaluate the efficacy of a protease-modulating dressing in the treatment
of neuropathic diabetic foot ulcers.
MATERIAL AND METHOD: A randomized controlled trial was conducted in 40 patients
with a 6-week or longer history of neuropathic diabetic foot ulcer. The patients
were randomized to two groups: group 1 (n = 20) received treatment with the
protease-modulating dressing while the control group (group 2; n = 20) received
the treatment specified in the standardized protocol for good wound care. The
patients were then followed-up for 6 weeks.
RESULTS: After 6 weeks, healing was achieved in 12 patients (63% of n = 19) in
group 1 under treatment with the protease-modulating dressing versus three
patients (15% of n = 19) in the control group (p < 0.03). The mean time to
healing was 23.3 +/- 9.9 days in group 1 and 40.6 +/- 1.15 days in group 2 (p <
0.01).
CONCLUSIONS: The results confirm the hypothesis that the use of
protease-modulating dressings in patients with neuropathic diabetic foot ulcers
leads to better tissue regeneration than good wound care.
PMID: 17580028 [Indexed for MEDLINE]
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