Shin JY, Roh SG, Sharaf B, Lee NH, et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS. Date of publication 2017 Dec 1;volume 70(12):1681-1688.
1. J Plast Reconstr Aesthet Surg. 2017 Dec;70(12):1681-1688. doi:
10.1016/j.bjps.2017.07.015. Epub 2017 Aug 5.
Risk of major limb amputation in diabetic foot ulcer and accompanying disease:
A meta-analysis.
Shin JY(1), Roh SG(2), Sharaf B(3), Lee NH(1).
Author information:
(1)Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk
National University, Jeonju, Republic of Korea; Research Institute of Clinical
Medicine-Biomedical Research Institute of Chonbuk National University Hospital,
Jeonju, Republic of Korea.
(2)Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk
National University, Jeonju, Republic of Korea; Research Institute of Clinical
Medicine-Biomedical Research Institute of Chonbuk National University Hospital,
Jeonju, Republic of Korea; Division of Plastic Surgery, Department of Surgery,
Mayo Clinic, Rochester, MN, USA. Electronic address: pssroh@jbnu.ac.kr.
(3)Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester,
MN, USA.
BACKGROUND: Limb amputation in diabetic patients raises important issues
regarding low quality of life and survival rates. This meta-analysis aimed to
identify predictive factors accompanying diseases with high major amputation
rates in diabetic patients.
METHODS: A systematic literature review and meta-analysis were performed using
MEDLINE, EMBASE and Cochrane databases. Eight variables were extracted from the
included studies and evaluated according to major amputation rates. The
Newcastle-Ottawa scale (NOS) was utilized to assess the quality of the studies.
RESULTS: The search strategy identified 101 publications. After screening, 10
articles were selected for review. Hypertension, ischemic heart disease,
cerebrovascular disease, and peripheral vascular disease were identified as
predictive variables of higher major amputation rates.
CONCLUSIONS: Although further investigation of long-term and prospective studies
is needed, we identified four variables as predisposing factors for higher major
amputation in diabetic patients through meta-analysis.
Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic
Surgeons. Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.bjps.2017.07.015
PMID: 28865989 [Indexed for MEDLINE]
