Nicoletti G, Brenta F, Bleve M, Pellegatta T, Malovini A, Faga A, Perugini P, et al.
Journal of tissue engineering and regenerative medicine. Date of publication 2015 Apr 1;volume 9(4):460-8.
1. J Tissue Eng Regen Med. 2015 Apr;9(4):460-8. doi: 10.1002/term.1939. Epub 2014
Jun 24.
Long-term in vivo assessment of bioengineered skin substitutes: a clinical study.
Nicoletti G(1), Brenta F, Bleve M, Pellegatta T, Malovini A, Faga A, Perugini P.
Author information:
(1)Department of Clinical Surgical Diagnostic and Paediatric Sciences, University
of Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive
Surgery Research Centre, University of Pavia, Italy; Plastic and Reconstructive
Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy.
The aim of the study was an objective in vivo assessment of skin properties after
reconstruction with two artificial dermal substitutes, Integra® and Hyalomatrix®.
Twenty-seven patients underwent reconstruction of 36 skin-loss sites with
full-thickness skin graft, split-thickness skin graft, Hyalomatrix® bioengineered
skin substitute and sequential split-thickness skin graft and Integra®
bioengineered skin substitute and sequential split-thickness skin graft.
Objective assessments were carried out using three instrumental devices: Multi
Probe Adapter System MPA; 22 MHz ultrasound skin scan; and Primos Pico for a
three-dimensional (3D) skin scan. The skin parameters under study in our sample
were: corneometry, transepidermal water loss, elastometry, colorimetry, skin
thickness and 3D skin surface pattern. A skin reconstruction with Hyalomatrix
seemed to most closely approach the hydration, transepidermal water loss and skin
surface 3D pattern of normal skin. A skin reconstruction with Integra seemed to
demonstrate the best skin colour feature and elastic properties. Although no
statistically significant differences were observed, the descriptive analysis of
the outcomes might suggest a better cell regulation, regenerated extracellular
matrix and neoangiogenesis with the use of Hyalomatrix, and the formation of a
more elastic regenerated dermis, with overall better physical, mechanical and
optical properties, with the use of Integra.
© 2014 The Authors. Journal of Tissue Engineering and Regenerative Medicine
published by John Wiley & Sons Ltd.
DOI: 10.1002/term.1939
PMID: 24962375 [Indexed for MEDLINE]
