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Nicoletti G, Brenta F, Bleve M, Pellegatta T, Malovini A, Faga A, Perugini P, et al.
Journal of tissue engineering and regenerative medicine. Date of publication 2015 Apr 1;volume 9(4):460-8.
1. J Tissue Eng Regen Med. 2015 Apr;9(4):460-8. doi: 10.1002/term.1939. Epub 2014 Jun 24. Long-term in vivo assessment of bioengineered skin substitutes: a clinical study. Nicoletti G(1), Brenta F, Bleve M, Pellegatta T, Malovini A, Faga A, Perugini P. Author information: (1)Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Centre, University of Pavia, Italy; Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy. The aim of the study was an objective in vivo assessment of skin properties after reconstruction with two artificial dermal substitutes, Integra® and Hyalomatrix®. Twenty-seven patients underwent reconstruction of 36 skin-loss sites with full-thickness skin graft, split-thickness skin graft, Hyalomatrix® bioengineered skin substitute and sequential split-thickness skin graft and Integra® bioengineered skin substitute and sequential split-thickness skin graft. Objective assessments were carried out using three instrumental devices: Multi Probe Adapter System MPA; 22 MHz ultrasound skin scan; and Primos Pico for a three-dimensional (3D) skin scan. The skin parameters under study in our sample were: corneometry, transepidermal water loss, elastometry, colorimetry, skin thickness and 3D skin surface pattern. A skin reconstruction with Hyalomatrix seemed to most closely approach the hydration, transepidermal water loss and skin surface 3D pattern of normal skin. A skin reconstruction with Integra seemed to demonstrate the best skin colour feature and elastic properties. Although no statistically significant differences were observed, the descriptive analysis of the outcomes might suggest a better cell regulation, regenerated extracellular matrix and neoangiogenesis with the use of Hyalomatrix, and the formation of a more elastic regenerated dermis, with overall better physical, mechanical and optical properties, with the use of Integra. © 2014 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons Ltd. DOI: 10.1002/term.1939 PMID: 24962375 [Indexed for MEDLINE]
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