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Lagus H, Sarlomo-Rikala M, Böhling T, Vuola J, et al.
Burns : journal of the International Society for Burn Injuries. Date of publication 2013 Dec 1;volume 39(8):1577-87.
1. Burns. 2013 Dec;39(8):1577-87. doi: 10.1016/j.burns.2013.04.023. Epub 2013 Jul 20. Prospective study on burns treated with Integra®, a cellulose sponge and split thickness skin graft: comparative clinical and histological study--randomized controlled trial. Lagus H(1), Sarlomo-Rikala M, Böhling T, Vuola J. Author information: (1)Department of Surgery, Hyvinkää Hospital, Hyvinkää, Finland. Electronic address: heli.lagus@hus.fi. BACKGROUND: The aim of this study was to compare three different methods to cover excised burn wounds in a randomized controlled trial. METHODS: Fascially excised burn wounds, measuring 10 cm × 5 cm, were covered with Integra(®), split thickness skin graft (STSG), and a viscose cellulose sponge Cellonex™ in each of ten adult patients. Integra(®) and Cellonex™ treated areas were covered with thin STSG on day 14. Biopsies were taken 3, 7, 14, and 21 days, 3 months, and 12 months after surgery, and samples were subjected to a range of immunohistochemical stains, in addition to hematoxylin and eosin (HE). Scar assessment was performed 3 and 12 months post-operatively with the Vancouver Scar Scale (VSS). RESULTS: Inflammation was not substantial in any of the study areas, but Cellonex™ had the most neutrophils, histiocytes, and lymphocytes with significant differences on days 7 and 14. Complete vascularization of Integra(®) seemed to occur later compared to the other materials. STSG had the most myofibroblasts on day 14 (p = 0.012). In VSS the quality of the scar improved in all materials from 3 to 12 months. CONCLUSIONS: The final results for all treatments after 12 months demonstrate equal clinical appearance, as well as histological and immunohistochemical findings. Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved. DOI: 10.1016/j.burns.2013.04.023 PMID: 23880091 [Indexed for MEDLINE]
Appears in following Topics:
Cellular and/or Tissue Based Products
Acute Burns - Treatment