Selig HF, Keck M, Lumenta DB, Mittlböck M, Kamolz LP, et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the Eur.... Date of publication 2013 May 1;volume 21(3):402-9.
1. Wound Repair Regen. 2013 May-Jun;21(3):402-9. doi: 10.1111/wrr.12050. Epub 2013
Apr 29.
The use of a polylactide-based copolymer as a temporary skin substitute in deep
dermal burns: 1-year follow-up results of a prospective clinical noninferiority
trial.
Selig HF(1), Keck M, Lumenta DB, Mittlböck M, Kamolz LP.
Author information:
(1)Vienna Burn Center, Division of Plastic and Reconstructive Surgery, Department
of Surgery, Medical University of Vienna, Vienna, Austria. selighf@gmail.com
Deep dermal burns can be covered with different kind of materials and techniques;
one of them is a polylactide-based temporary skin substitute. The aim of this
study was to intraindividually compare its 1-year outcome with the results
obtained by use of autologous skin grafts in patients suffering from deep dermal
burns. A prospective noninferiority trial was designed in order to assess skin
quality and scar formation by use of subjective (Vancouver Scar Scale; Patient
and Observer Scar Assessment Scale) and objective (noninvasive cutometry) burn
scar assessment tools. All items of the Patient and Observer Scar Assessment
Scale, except vascularity, were found to be noninferior in the areas covered with
the temporary skin substitute vs. autologous skin. Results of objective scar
evaluation showed comparable viscoelastic parameters without reaching
noninferiority. Overall, the outcome of deep dermal burns covered with a
polylactide-based temporary skin substitute revealed satisfactory results in
terms of scar formation and skin quality as compared with autologous skin. This
paper supports its use in deep dermal burns, where autologous skin donor sites
require either to be reserved for coverage of full-thickness skin defects in
severe burns or to be saved for reduction of additional morbidity in selected
patient collectives.
© 2013 by the Wound Healing Society.
DOI: 10.1111/wrr.12050
PMID: 23627672 [Indexed for MEDLINE]
