Romanelli M, Dini V, Bertone M, Barbanera S, Brilli C, et al.
International wound journal. Date of publication 2007 Mar 1;volume 4(1):3-7.
1. Int Wound J. 2007 Mar;4(1):3-7.
OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds
of mixed arterial/venous aetiology.
Romanelli M(1), Dini V, Bertone M, Barbanera S, Brilli C.
Author information:
(1)Wound Healing Research Unit, Department of Dermatology, University of Pisa,
Pisa, Italy. m.romanelli@med.unipit.it
Mixed arterial/venous (A/V) ulcers are difficult to treat and slow to heal likely
as a result of deficiencies in molecular and cellular elements in the wound bed.
Recently, biomaterials have been developed that replace extracellular matrix
(ECM) molecules and growth factors critical to the normal healing process. In
this study, the effects of OASIS and Hyaloskin were evaluated to compare the
effectiveness of these two ECM-based products in their ability to achieve
complete wound healing of mixed A/V ulcers. After 16 weeks of treatment, patients
in each group were evaluated on four criteria: complete wound healing, time to
dressing change, pain and comfort. Complete wound closure was achieved in 82.6%
of OASIS-treated ulcers compared with 46.2% of Hyaloskin-treated ulcers (P <
0.001). Statistically significant differences favouring the OASIS treatment group
were also reported for time to dressing change (P < 0.05), pain (P < 0.05) and
patient comfort (P < 0.01). Overall, OASIS was superior to Hyaloskin for the
treatment of patients with mixed A/V ulcers, a population in which standard
treatment options largely consist of moist wound dressings and compression
therapy is typically not an option. OASIS is a useful and well-tolerated
treatment for mixed A/V ulcers that has the potential to improve quality of life
and reduce costs associated with standard of care.
DOI: 10.1111/j.1742-481X.2007.00300.x
PMID: 17425543 [Indexed for MEDLINE]
