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Romanelli M, Dini V, Bertone MS, et al.
Advances in skin & wound care. Date of publication 2010 Jan 1;volume 23(1):34-8.
1. Adv Skin Wound Care. 2010 Jan;23(1):34-8. doi: 10.1097/01.ASW.0000363485.17224.26. Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/venous etiology. Romanelli M(1), Dini V, Bertone MS. Author information: (1)Department of Dermatology, University of Pisa, Italy. OBJECTIVE: In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers. METHODS: Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue. RESULTS: Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05). CONCLUSION: Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers. DOI: 10.1097/01.ASW.0000363485.17224.26 PMID: 20101114 [Indexed for MEDLINE]
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