Purdue GF, Hunt JL, Still JM Jr, Law EJ, Herndon DN, Goldfarb IW, Schiller WR, Hansbrough JF, Hickerson WL, Himel HN, Kealey GP, Twomey J, Missavage AE, Solem LD, Davis M, Totoritis M, Gentzkow GD, et al.
The Journal of burn care & rehabilitation. Date of publication 1997 Jan 1;volume 18(1 Pt 1):52-7.
1. J Burn Care Rehabil. 1997 Jan-Feb;18(1 Pt 1):52-7.
A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC,
compared with cryopreserved human cadaver skin for temporary coverage of excised
burn wounds.
Purdue GF(1), Hunt JL, Still JM Jr, Law EJ, Herndon DN, Goldfarb IW, Schiller WR,
Hansbrough JF, Hickerson WL, Himel HN, Kealey GP, Twomey J, Missavage AE, Solem
LD, Davis M, Totoritis M, Gentzkow GD.
Author information:
(1)Department of Surgery, University of Texas, Southwestern Medical Center,
Dallas 75235-9031, USA.
This multicenter study compared the use of a biosynthetic human skin substitute
with frozen human cadaver allograft for the temporary closure of excised burn
wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists of a
synthetic material onto which human neonatal fibroblasts are cultured. Burn
wounds in 66 patients with a mean age of 36 years and a mean burn size of 44%
total body surface area (28% total body surface area full-thickness) were
surgically excised. Two comparable sites, each approximately 1% total body
surface area in size, were randomized to receive either DG-TC or allograft. Both
sites were then treated in the same manner. When clinically indicated (> 5 days
after application) both skin replacements were removed, and the wound beds were
evaluated and prepared for grafting. DG-TC was equivalent or superior to
allograft with regard to autograft take at postautograft day 14. DG-TC was also
easier to remove, had no epidermal slough, and resulted in less bleeding than did
allograft while maintaining an adequate wound bed. Overall satisfaction was
better with DG-TC.
PMID: 9063788 [Indexed for MEDLINE]
