Brigido SA, Boc SF, Lopez RC, et al.
Orthopedics. Date of publication 2004 Jan 1;volume 27(1 Suppl):s145-9.
1. Orthopedics. 2004 Jan;27(1 Suppl):s145-9.
Effective management of major lower extremity wounds using an acellular
regenerative tissue matrix: a pilot study.
Brigido SA(1), Boc SF, Lopez RC.
Author information:
(1)St. Agnes Medical Center, Philadelphia, Pa, USA.
Wound healing is a significant problem in orthopedics. Graftjacket tissue matrix
(Wright Medical Technology, Inc, Arlington, Tenn), a novel acellular regenerative
tissue matrix, has been designed to aid wound closure. A prospective, randomized
study was initiated to determine the efficacy of this tissue product in wound
repair compared with conventional treatment. Lower extremity wounds are
refractile to healing in patients with diabetes mellitus. Therefore, researchers
used diabetic foot ulcers to evaluate the efficacy of GraftJacket tissue matrix
in wound repair. Only a single administration of the tissue matrix was required.
After 1 month of treatment, preliminary results demonstrate that this novel
tissue matrix promotes faster healing at a statistically significant rate over
conventional treatment. Because wounds in this series of patients are deep and
circulation around the wound is poor, the preliminary results suggest that this
tissue matrix will be applicable to other types of orthopedic wounds.
PMID: 14763548 [Indexed for MEDLINE]
