Bhardwaj N, Chouhan D, Mandal BB, et al.
Current pharmaceutical design. Date of publication 2017 Jan 1;volume 23(24):3455-3482.
1. Curr Pharm Des. 2017;23(24):3455-3482. doi: 10.2174/1381612823666170526094606.
Tissue Engineered Skin and Wound Healing: Current Strategies and Future
Directions.
Bhardwaj N(1), Chouhan D(2), Mandal BB(2).
Author information:
(1)DBT BioCARe Scientist, Institute of Advanced Study in Science and Technology
(IASST), Guwahati. India.
(2)Biomaterials and Tissue Engineering Laboratory, Department of Biosciences and
Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039. India.
The global volume of skin damage or injuries has major healthcare implications
and, accounts for about half of the world's annual expenditure in the healthcare
sector. In the last two decades, tissue-engineered skin constructs have shown
great promise in the treatment of various skin-related disorders such as deep
burns and wounds. The treatment methods for skin replacement and repair have
evolved from utilization of autologous epidermal sheets to more complex bilayered
cutaneous tissue engineered skin substitutes. However, inadequate
vascularization, lack of flexibility in drug/growth factors loading and inability
to reconstitute skin appendages such as hair follicles limits their utilization
for restoration of normal skin anatomy on a routine basis. Recent advancements in
cutting-edge technology from stem cell biology, nanotechnology, and various
vascularization strategies have provided a tremendous springboard for researchers
in developing and manipulating tissue engineered skin substitutes for improved
skin regeneration and wound healing. This review summarizes the overview of skin
tissue engineering and wound healing. Herein, developments and challenges of
various available biomaterials, cell sources and in vitro skin models (full
thickness and wound healing models) in tissue-engineered skin research are
discussed. Furthermore, central to the discussion is the inclusion of various
innovative strategies starting from stem cells, nanotechnology, vascularization
strategies, microfluidics to three dimensional (3D) bioprinting based strategies
for generation of complex skin mimics. The review then moves on to highlight the
future prospects of advanced construction strategies of these bioengineered skin
constructs and their contribution to wound healing and skin regeneration on
current practice.
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DOI: 10.2174/1381612823666170526094606
PMID: 28552069 [Indexed for MEDLINE]
