Lazic T, Falanga V, et al.
Plastic and reconstructive surgery. Date of publication 2011 Jan 1;volume 127 Suppl 1():75S-90S.
1. Plast Reconstr Surg. 2011 Jan;127 Suppl 1:75S-90S. doi:
10.1097/PRS.0b013e3182009d9f.
Bioengineered skin constructs and their use in wound healing.
Lazic T(1), Falanga V.
Author information:
(1)Department of Dermatology and the National Institutes of Health Center of
Biomedical Research Excellence, Roger Williams Medical Center, Rovidence, RI,
USA.
Comment in
Plast Reconstr Surg. 2011 Jan;127 Suppl 1:91S-92S.
BACKGROUND: Over the past two decades, the field of wound healing and tissue
repair has witnessed tremendous advances resulting from the biological sciences,
biomedical and tissue engineering, and greater clinical understanding of wounds
and their pathophysiology. In large part because of these advances, clinicians
are now able to offer and deliver more sophisticated and effective treatments to
patients with acute wounds, chronic wounds, burns, and other types of injuries.
METHODS: This report relies on published information focused on bioengineered
skin and the authors' perspectives on the application of this technology in wound
healing. In some cases, off-label applications of certain bioengineered skin
constructs have been used to illustrate the spectrum of usefulness of these
constructs.
RESULTS: Bioengineered skin (including acellular and cellular products; living
and nonliving constructs; and epidermal, dermal, and bilayered therapeutic
adjuncts) has resulted in very substantial and demonstrable improvements in wound
care. Some of the constructs are U.S. Food and Drug Administration approved for
treatment of burns and for impaired healing situations, including venous and
diabetic foot ulcers.
CONCLUSIONS: The advances that have occurred in testing and proving the efficacy
of bioengineered skin hold great promise for further improvements in the way this
technology is used in the surgical field and in wound care. Advances in
therapeutic agents have also led to greater understanding of pathophysiology.
Thus, wound bed preparation as a concept and as an approach is in fact the result
of the need to maximize the benefits of advanced therapies.
DOI: 10.1097/PRS.0b013e3182009d9f
PMID: 21200276 [Indexed for MEDLINE]
