Goodarzi P, Falahzadeh K, Nematizadeh M, Farazandeh P, Payab M, Larijani B, Tayanloo Beik A, Arjmand B, et al.
Advances in experimental medicine and biology. Date of publication 2018 Jun 1;volume ():.
1. Adv Exp Med Biol. 2018 Jun 1. doi: 10.1007/5584_2018_226. [Epub ahead of print]
Tissue Engineered Skin Substitutes.
Goodarzi P(1), Falahzadeh K(2), Nematizadeh M(2), Farazandeh P(2), Payab M(3),
Larijani B(4), Tayanloo Beik A(5), Arjmand B(6).
Author information:
(1)Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran
University of Medical Sciences, Tehran, Iran.
(2)Metabolomics and Genomics Research Center, Endocrinology and Metabolism
Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences,
Tehran, Iran.
(3)Obesity and Eating Habits Research Center, Endocrinology and Metabolism
Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences,
Tehran, Iran.
(4)Endocrinology and Metabolism Research Center, Endocrinology and Metabolism
Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
(5)Cell Therapy and Regenerative Medicine Research Center, Endocrinology and
Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical
Sciences, Tehran, Iran.
(6)Cell Therapy and Regenerative Medicine Research Center, Endocrinology and
Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical
Sciences, Tehran, Iran. barjmand@sina.tums.ac.ir.
The fundamental skin role is to supply a supportive barrier to protect body
against harmful agents and injuries. Three layers of skin including epidermis,
dermis and hypodermis form a sophisticated tissue composed of extracellular
matrix (ECM) mainly made of collagens and glycosaminoglycans (GAGs) as a
scaffold, different cell types such as keratinocytes, fibroblasts and functional
cells embedded in the ECM. When the skin is injured, depends on its severity, the
majority of mentioned components are recruited to wound regeneration.
Additionally, different growth factors like fibroblast growth factor (FGF),
epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) are
needed to orchestrated wound healing process. In case of large surface area
wounds, natural wound repair seems inefficient. Inspired by nature, scientists in
tissue engineering field attempt to engineered constructs mimicking natural
healing process to promote skin restoration in untreatable injuries. There are
three main types of commercially available engineered skin substitutes including
epidermal, dermal, and dermoepidermal. Each of them could be composed of
scaffold, desired cell types or growth factors. These substitutes could have
autologous, allogeneic, or xenogeneic origin. Moreover, they may be cellular or
acellular. They are used to accelerate wound healing and recover normal skin
functions with pain relief. Although there are a wide variety of commercially
available skin substitutes, almost none of them considered as an ideal
equivalents required for proper wound healing.
DOI: 10.1007/5584_2018_226
PMID: 29855826
