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Nicholas MN, Yeung J, et al.
Journal of cutaneous medicine and surgery. Date of publication 2017 Jan 1;volume 21(1):23-30.
1. J Cutan Med Surg. 2017 Jan/Feb;21(1):23-30. doi: 10.1177/1203475416664037. Epub 2016 Aug 20. Current Status and Future of Skin Substitutes for Chronic Wound Healing. Nicholas MN(1), Yeung J(2)(3). Author information: (1)1 Faculty of Medicine, University of Toronto, Toronto, ON, Canada. (2)2 Department of Dermatology, Women's College Hospital and Sunnybrook Health Sciences Centre, Toronto, ON, Canada. (3)3 Division of Dermatology, University of Toronto, Toronto, ON, Canada. Chronic wounds, including diabetic ulcers, pressure ulcers, venous ulcers, and arterial insufficiency ulcers, are both difficult and expensive to treat. Conventional wound care may sometimes lead to suboptimal wound healing and significant morbidity and mortality for patients. The use of skin substitutes provides an alternative therapy showing superior efficacy and, in some cases, similar cost-effectiveness compared to traditional treatments. This review discusses the different types of currently available commercial skin substitutes for use in chronic wounds as well as the paucity of strong evidence supporting their use. It then delves into the limitations of these skin substitutes and examines the most recent research targeting these limitations. DOI: 10.1177/1203475416664037 PMID: 27530398 [Indexed for MEDLINE]
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