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Towler MA, Rush EW, Richardson MK, Williams CL, et al.
Clinics in podiatric medicine and surgery. Date of publication 2018 Jul 1;volume 35(3):357-365.
1. Clin Podiatr Med Surg. 2018 Jul;35(3):357-365. doi: 10.1016/j.cpm.2018.02.006. Epub 2018 Apr 14. Randomized, Prospective, Blinded-Enrollment, Head-To-Head Venous Leg Ulcer Healing Trial Comparing Living, Bioengineered Skin Graft Substitute (Apligraf) with Living, Cryopreserved, Human Skin Allograft (TheraSkin). Towler MA(1), Rush EW(2), Richardson MK(2), Williams CL(3). Author information: (1)Bon Secours St Francis Wound Healing Center, Suite 100, 131 Commonwealth Drive, Greenville, SC 29615, USA. Electronic address: mtowler@charter.net. (2)Bon Secours St Francis Wound Healing Center, Suite 100, 131 Commonwealth Drive, Greenville, SC 29615, USA. (3)Department of Mathematical Sciences, Center for Excellence in Mathematics and Science Education, Clemson University, 0-323 Martin Hall, Clemson, SC 29634-0975, USA. Chronic venous leg ulcers are responsible for significant morbidity and health care costs worldwide. This pilot study evaluated the effectiveness 2 biologically active grafts, TheraSkin and Apligraf, in conjunction with compression therapy. The study, not industry-sponsored, was designed and conducted as a prospective, head-to-head, single-site, randomized clinical trial to assess differences in healing rates, adverse outcomes, and treatment costs. The healing rates were different but not statistically significant, there were no adverse outcomes, and TheraSkin averaged $2495.33 and Apligraf averaged $4316.67 per subject. This suggests that TheraSkin may provide equivalent or superior outcomes to Apligraf while reducing costs. Copyright © 2018 Elsevier Inc. All rights reserved. DOI: 10.1016/j.cpm.2018.02.006 PMID: 29861018
Appears in following Topics:
Venous Ulcers - Treatment and Prevention
Cellular and/or Tissue Based Products
Lymphedema - Treatment and Emerging Strategies for Prevention