Moneib HA, Youssef SS, Aly DG, Rizk MA, Abdelhakeem YI, et al.
Journal of cosmetic dermatology. Date of publication 2018 Jun 1;volume 17(3):495-501.
1. J Cosmet Dermatol. 2018 Jun;17(3):495-501. doi: 10.1111/jocd.12401. Epub 2017 Aug
19.
Autologous platelet-rich plasma versus conventional therapy for the treatment of
chronic venous leg ulcers: A comparative study.
Moneib HA(1), Youssef SS(1), Aly DG(2), Rizk MA(3), Abdelhakeem YI(4).
Author information:
(1)Department of Dermatology, Venereology and Andrology, Ain Shams University,
Cairo, Egypt.
(2)Department of Dermatology and Venereology, National Research Centre, Giza,
Egypt.
(3)Department of Vascular Surgery, Ain Shams University, Cairo, Egypt.
(4)Al Haud Almarsoud Hospital, Cairo, Egypt.
BACKGROUND: Chronic venous leg ulcers drastically reduce the quality of life of
affected patients. There is heightened interest in autologous platelet-rich
plasma (PRP) as one of the promising therapies for leg ulcers.
AIM: Our aim was to compare the clinical efficacy of PRP in the management of
chronic venous leg ulcers vs conventional treatment.
PATIENTS/METHODS: In total, 40 patients with chronic venous leg ulcers were
included in the study. Twenty patients were treated with autologous PRP weekly
for 6 weeks (Group A), and 20 patients were treated with conventional treatment
(compression and dressing) for 6 weeks (Group B). Treatment results were
calculated by percentage of improvement in area of the ulcer.
RESULTS: Compared to conventional therapy, a highly significant improvement in
the ulcer size was observed post-PRP therapy (P-value = .0001). The mean change
in the area of the ulcer post-PRP and conventional therapy was 4.92 ± 11.94 cm
and 0.13 ± 0.27 cm, respectively, while the mean percentage improvement in the
area of the ulcer post-PRP and conventional therapy was 67.6% ± 36.6% and 13.67%
± 28.06%, respectively. Subjective improvement in pain associated with the ulcer
was noted by all patients.
CONCLUSIONS: Platelet-rich plasma is a safe nonsurgical procedure for treating
chronic venous leg ulcers. Additional studies with larger sample size and longer
follow-up periods are required to confirm or refute our findings.
© 2017 Wiley Periodicals, Inc.
DOI: 10.1111/jocd.12401
PMID: 28834103
