Bower M, Stein R, Evans TR, Hedley A, Pert P, Coombes RC, et al.
European journal of cancer (Oxford, England : 1990). Date of publication 1992 Jan 1;volume 28A(4-5):888-9.
1. Eur J Cancer. 1992;28A(4-5):888-9.
A double-blind study of the efficacy of metronidazole gel in the treatment of
malodorous fungating tumours.
Bower M(1), Stein R, Evans TR, Hedley A, Pert P, Coombes RC.
Author information:
(1)Medical Oncology Department, Charing Cross Hospital, London, U.K.
A double-blind placebo-controlled trial was undertaken to assess the value of
topical metronidazole gel preparation in the palliation of the offensive odour of
fungating tumours. This 5 day trial was followed by a 6 day period during which
all patients received the active gel. Subjective odour assessments were performed
by both patients and medical staff. 11 patients were entered and the
randomisation was then halted because of an obvious overall benefit over the
whole 11 days. There was a non-significant trend in favour of the active
treatment during the initial double-blind placebo-controlled phase of the trial,
and no side-effects were observed.
PMID: 1524917 [Indexed for MEDLINE]
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