Nímia HH, Carvalho VF, Isaac C, Souza FÁ, Gemperli R, Paggiaro AO, et al.
Burns : journal of the International Society for Burn Injuries. Date of publication 2018 Jun 11;volume ():.
1. Burns. 2018 Jun 11. pii: S0305-4179(18)30399-1. doi: 10.1016/j.burns.2018.05.014.
[Epub ahead of print]
Comparative study of Silver Sulfadiazine with other materials for healing and
infection prevention in burns: A systematic review and meta-analysis.
Nímia HH(1), Carvalho VF(2), Isaac C(3), Souza FÁ(4), Gemperli R(5), Paggiaro
AO(6).
Author information:
(1)Guarulhos University, Nursing Post, Graduation Program, Praça Tereza Cristina,
88, Centro, Guarulhos, SP, 07020-071, Brazil. Electronic address:
helonimia@pucpcaldas.br.
(2)Guarulhos University, Nursing Post, Graduation Program, Praça Tereza Cristina,
88, Centro, Guarulhos, SP, 07020-071, Brazil. Electronic address:
vcarvalho@prof.ung.br.
(3)São Paulo University, Plastic Surgery Division, Av. Dr. Arnaldo, 455,
Cerqueira César, São Paulo, SP, 01246-903, Brazil. Electronic address:
cesar.isaac@hc.fm.usp.br.
(4)Dentistry College, UNESP, Rua José Bonifácio, 1193, Araçatuba, São Paulo, SP,
16015-050, Brazil. Electronic address: f.avilasouza@foa.unesp.br.
(5)São Paulo University, Plastic Surgery Division, Av. Dr. Arnaldo, 455,
Cerqueira César, São Paulo, SP, 01246-903, Brazil. Electronic address:
rolf.gemperli@hc.fm.usp.br.
(6)Guarulhos University, Nursing Post, Graduation Program, Praça Tereza Cristina,
88, Centro, Guarulhos, SP, 07020-071, Brazil. Electronic address:
apaggiaro@prof.ung.br.
The aim of this systematic review with meta-analysis was to compare the effect of
Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on
healing and infection prevention in burns. The electronic search was carried out
in the electronic databases of Pubmed, ScienceDirect, Lilacs and BVS. The
articles included were randomized clinical trials about burn treatment with SSD,
which evaluated the healing and infection of burn wounds in humans. The exclusion
criteria included articles, editorials and letters published in the form of
abstracts, unpublished reports and case series, cross-sectional, observational
experimental studies, and the use of sulfadiazine for other types of wounds. The
search identified 873 references, and 24 studies were included in accordance with
the eligibility criteria. The results showed a statistically favorable difference
related to the time of healing for silver dressings (p<0.0001; MD 3.83; 95% CI
2.03-5.62) and dressings without silver (p<0.007; MD 2.9; 95% CI 0.81-5.00) in
comparison with SSD. The rate of infection showed no difference in the group
treated with SSD compared with the group treated with dressings containing silver
(p>0.05). The rate of infection was significantly higher in the SSD group
compared with the group treated with dressings without silver (p<0.005; MD 25.29%
and MD 12.97%). Considering the clinical trials conducted up to the present time,
the authors concluded that new dressings with and without silver show better
results than SSD for wound healing, and burns treated with dressings without
silver are less likely to become infected than burns with SSD. No differences
between SSD and new silver materials were observed in relation to infection
prevention.
Copyright © 2018 Elsevier Ltd and ISBI. All rights reserved.
DOI: 10.1016/j.burns.2018.05.014
PMID: 29903603
