Patry J, Blanchette V, et al.
International wound journal. Date of publication 2017 Dec 1;volume 14(6):1055-1065.
1. Int Wound J. 2017 Dec;14(6):1055-1065. doi: 10.1111/iwj.12760. Epub 2017 Apr 25.
Enzymatic debridement with collagenase in wounds and ulcers: a systematic review
and meta-analysis.
Patry J(1)(2)(3), Blanchette V(3).
Author information:
(1)Family Medicine and Emergency Medicine Department, Faculty of Medicine,
Université Laval, Québec, Canada.
(2)Complex Wound Care Clinic and Hyperbaric Unit, Centre Hospitalier Affilié
Universitaire Hôtel-Dieu de Lévis, Lévis, Canada.
(3)Physical Activity Sciences Department, Podiatric Medicine Unit, Université du
Québec à Trois-Rivières, Trois-Rivières, Canada.
Enzymatic debridement with collagenase is a technique that is commonly used in
clinical practice. This systematic review examines the effect of collagenase on
all kinds of wounds, compared to an alternative therapy, on wound healing, wound
bed characteristics, cost-effectiveness and the occurrence of adverse events. We
conducted a systematic literature search on available literature in Cochrane
databases, MEDLINE, EMBASE and CINAHL. Two investigators independently assessed
the titles and abstracts of all randomised controlled trials obtained involving
collagenase of all kinds of wounds based on inclusion criteria. Of the 1411
citations retrieved, 22 studies reported outcomes with the use of collagenase
either for wound healing or wound debridement. Results support the use of
collagenase for enzymatic debridement in pressure ulcers, diabetic foot ulcers
and in conjunction with topical antibiotics for burns. However, studies presented
a high risk of bias. Risk ratio of developing an adverse event related to
collagenase versus the alternative treatment was statistically significant (for
10 studies, RR: 1·79, 95% CI 1·24-2·59, I2 =0%, P = 0·002). There is very limited
data on the effect of collagenase as an enzymatic debridement technique on
wounds. More independant research and adequate reporting of adverse events are
warranted.
© 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
DOI: 10.1111/iwj.12760
PMID: 28440050 [Indexed for MEDLINE]
