Ahmed M, Reffat SA, Hassan A, Eskander F, et al.
Annals of vascular surgery. Date of publication 2017 Jan 1;volume 38():206-211.
1. Ann Vasc Surg. 2017 Jan;38:206-211. doi: 10.1016/j.avsg.2016.04.023. Epub 2016
Aug 12.
Platelet-Rich Plasma for the Treatment of Clean Diabetic Foot Ulcers.
Ahmed M(1), Reffat SA(2), Hassan A(1), Eskander F(1).
Author information:
(1)Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt.
(2)Department of Surgery, Suez Canal University, Ismailia, Egypt. Electronic
address: shrefat@hotmail.com.
BACKGROUND: Diabetic foot ulcer is considered as a major health problem that
predisposes to limb amputation. Among the different methods to achieve ulcer
healing, platelet-rich plasma (PRP) gel is gaining popularity. It is thought to
stimulate wound closure by providing essential growth factors for healing. This
study aims to evaluate the value of autologous PRP gel in the treatment of
diabetic ulcers.
METHODS: The study included 56 patients of both sex from 18 to 80 years, with
clean chronic diabetic foot ulcers divided into 2 equal groups. The first group
was treated by antiseptic ointment dressing, and the second group was treated by
autologous platelet gel. PRP together with thrombin were prepared by
centrifugation at each dressing session. Thrombin and calcium chloride were used
to activate the PRP. The formed platelet gel was applied to the wound twice
weekly.
RESULTS: Statically significant increase in healing rate was found in the
PRP-treated group, and complete healing was achieved in 86% of them in comparison
to 68% of the control group. In the study group, rate of healing per week was
greater during the first 8 weeks and starts to decline afterward. The use of
platelet gel showed a lower rate of wound infection.
CONCLUSIONS: Autologous platelet gel is more effective than the local antiseptic
dressing in terms of healing rate and prevention of infection in clean diabetic
ulcers.
Copyright © 2016 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.avsg.2016.04.023
PMID: 27522981 [Indexed for MEDLINE]
