Mathur RK, Sahu K, Saraf S, Patheja P, Khan F, Gupta PK, et al.
Lasers in medical science. Date of publication 2017 Feb 1;volume 32(2):275-282.
1. Lasers Med Sci. 2017 Feb;32(2):275-282. doi: 10.1007/s10103-016-2109-2. Epub 2016
Nov 29.
Low-level laser therapy as an adjunct to conventional therapy in the treatment of
diabetic foot ulcers.
Mathur RK(1), Sahu K(2), Saraf S(3), Patheja P(4), Khan F(1), Gupta PK(4).
Author information:
(1)Department of Surgery, Mahatma Gandhi Memorial Medical College, Maharaja
Yashwantrao Hospital, 101, vishnupuri main, A.B. Road, Indore, Madhya Pradesh,
452001, India.
(2)Laser Biomedical Applications and Instrumentation Division, Raja Ramanna
Centre for Advanced Technology, Indore, Madhya Pradesh, 452013, India.
khageswar@rrcat.gov.in.
(3)Department of Surgery, Mahatma Gandhi Memorial Medical College, Maharaja
Yashwantrao Hospital, 101, vishnupuri main, A.B. Road, Indore, Madhya Pradesh,
452001, India. siddharthsaraf18@gmail.com.
(4)Laser Biomedical Applications and Instrumentation Division, Raja Ramanna
Centre for Advanced Technology, Indore, Madhya Pradesh, 452013, India.
Foot ulcers are serious complications of diabetes mellitus (DM) and are known to
be resistant to conventional treatment. This study was conducted to evaluate the
efficacy of low-level laser therapy (LLLT) for the treatment of diabetic foot
ulcers in a tertiary care centre (Department of Surgery, Mahatma Gandhi Memorial
Medical College and Maharaja Yashwantrao Hospital, A.B. Road, Indore). A total of
30 patients with type 2 DM having Meggitt-Wagner grade I foot ulcers of more than
6 weeks duration with negative culture were studied. Patients were randomized
into two groups of 15 each. Patients in study group received LLLT (660 ± 20 nm,
3 J/cm2) along with conventional therapy and those in control group were treated
with conventional therapy alone. The primary outcome measure was the absolute and
relative wound size reduction at 2 weeks compared to the baseline parameter.
Percentage ulcer area reduction was 37 ± 9% in the LLLT group and 15 ± 5.4% in
the control group (p < 0.001). For ∼75% of wounds of the treatment group, wound
area reduction of 30-50% was observed. In contrast, for the control group, ∼80%
of wounds showed a wound area reduction of <20% on day 15. Further, the wounds
with initial wound area 1000-2000 mm2 seems to have better final outcome than the
groups with larger areas. The treated groups showed higher amount of granulation
than the control group. The results suggest that LLLT is beneficial as an adjunct
to conventional therapy in the treatment of diabetic foot ulcers.
DOI: 10.1007/s10103-016-2109-2
PMID: 27896528 [Indexed for MEDLINE]
