Landau Z, Migdal M, Lipovsky A, Lubart R, et al.
Photomedicine and laser surgery. Date of publication 2011 Jun 1;volume 29(6):399-404.
1. Photomed Laser Surg. 2011 Jun;29(6):399-404. doi: 10.1089/pho.2010.2858. Epub
2011 Jan 9.
Visible light-induced healing of diabetic or venous foot ulcers: a
placebo-controlled double-blind study.
Landau Z(1), Migdal M, Lipovsky A, Lubart R.
Author information:
(1)Department of Internal Medicine D, and the Diabetic Foot and Infectious
Diseases Unit, Kaplan Medical Center, Rehovot, Israel.
BACKGROUND AND OBJECTIVES: Non-healing ulcers represent a significant
dermatological problem. Recently, conventional therapy-resistant chronic ulcers
have been treated with low energy lasers or light-emitting diodes in the visible
and near IR region, but only a few placebo-controlled double-blind studies have
been performed to support the efficacy of this approach. The aim of the present
study was to evaluate the efficacy of a broadband (400-800 nm) visible light
device in the treatment of leg or foot ulcers.
METHODS: A placebo-controlled double-blind study using broadband light source
(400-800 nm) was performed on patients with diabetic foot ulcers or patients
with chronic leg ulcers. The treatment group was illuminated with 180 mW/cm(2)
broadband light twice a day for 4 min/session, while patients in the placebo
group received non-healing light fluency (10 mW/cm(2)) projections. The
treatment group included 10 patients with a total of 19 ulcers, whereas in the
placebo group, 6 patients had 6 ulcers. The follow-up period was 12 weeks.
RESULTS: At the end of the follow up, all the wounds were closed in 9 out of 10
patients (90%) from the treatment group, whereas in the placebo group only 2 out
of 6 patients exhibited closed wounds (33%). The reduction in wound size in the
treatment group versus the placebo group was 89% and 54%, respectively.
CONCLUSIONS: In this small scale placebo-controlled double-blind study, broadband
(400-800 nm) visible light was an effective modality for the treatment of leg or
foot ulcers.
DOI: 10.1089/pho.2010.2858
PMID: 21214497 [Indexed for MEDLINE]
