Zhang SS, Tang ZY, Fang P, Qian HJ, Xu L, Ning G, et al.
Experimental and therapeutic medicine. Date of publication 2013 Jan 1;volume 5(1):215-222.
1. Exp Ther Med. 2013 Jan;5(1):215-222. Epub 2012 Oct 30.
Nutritional status deteriorates as the severity of diabetic foot ulcers increases
and independently associates with prognosis.
Zhang SS(1), Tang ZY, Fang P, Qian HJ, Xu L, Ning G.
Author information:
(1)Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai
Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of
Endocrine and Metabolic Disease, Shanghai Jiao-Tong University School of
Medicine, Shanghai 200025, P.R. China.
The prognosis for diabetic foot ulcers (DFUs) remains poor. Nutritional status
has not been identified as one of the factors affecting the outcome of DFUs.
Therefore, indicators correlated with nutritional status and outcome were
analyzed to investigate their relationship. A total of 192 hospitalized patients
with Wagner grade 1-5 ulcers and 60 patients with Wagner grade 0 ulcers (all had
type 2 diabetes) were assessed by the following: subjective global assessment
(SGA), anthropometric measurements, biochemical indicators and physical
examinations to evaluate nutritional status, severity of infection and
complications. Patient outcome was recorded as healing of the ulcer and the
patients were followed up for 6 months or until the wound was healed. The
percentage of malnutrition was 62.0% in the DFU patients. The SGA was closely
correlated with infection (r=0.64), outcome (r=0.37) and BMI (r=-0.36), all
P<0.001. The risk of poor outcome increased with malnutrition [odds ratio (OR),
10.6, P<0.001]. The nutritional status of the DFU patients was independently
correlated with the severity of infection and outcome (both P<0.001) and Wagner
grades and nutritional status (SGA) were independent risk factors for patient
outcome (both P<0.001). Nutritional status deteriorated as the severity of the
DFU increased, and malnutrition was a predictor of poor prognosis.
DOI: 10.3892/etm.2012.780
PMCID: PMC3524099
PMID: 23251271
