Maier HM, Ilich JZ, Kim JS, Spicer MT, et al.
Skinmed. Date of publication 2013 Jul 1;volume 11(4):217-24; quiz 224-5.
1. Skinmed. 2013 Jul-Aug;11(4):217-24; quiz 224-5.
Nutrition supplementation for diabetic wound healing: a systematic review of
current literature.
Maier HM(1), Ilich JZ, Kim JS, Spicer MT.
Author information:
(1)Department of Nutrition, Food, and Exercise Sciences, The Florida State
University, Tallahassee, FL 32306, USA.
There are 25.8 million people with diabetes in the United States (Centers for
Disease Control and Prevention 2011 National Diabetes Fact Sheet). This number is
expected to increase by 1 million per year. Diabetic foot ulcers (DFUs) occur in
patients with a history of poorly controlled blood glucose. Almost 30% of people
with diabetes aged 40 years or older experience DFUs caused by an impaired nerve
sensation. It is one of the more persistent types of chronic wounds, which poses
an economic burden on individuals and society and reduces the quality of life of
patients and their families. This paper reviews the efficacy of nutrition
supplementation in diabetic wound healing, including both human and animal
studies. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses
methods, the search was conducted in PubMed and ISI's Web of Science databases.
Studies in which diabetic wounds/foot ulcers were treated with specific
nutritional or herbal suplements were selected. This review includes 4 human and
9 animal studies that met the criteria of the search. Positive outcomes in the
human studies were not significant while the nutritional supplements used in the
animal studies were effective and promoted wound healing. The most notable effect
of supplementation with curcumin, L-Arginine, or vitamin E have been shown in
animal sudies. More human studies need to be conducted to determine the efficacy
of these nutritional supplements in promoting wound healing.
PMID: 24053007 [Indexed for MEDLINE]
