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Ye J, Mani R, et al.
The international journal of lower extremity wounds. Date of publication 2016 Dec 1;volume 15(4):296-302.
1. Int J Low Extrem Wounds. 2016 Dec;15(4):296-302. doi: 10.1177/1534734616674624. Epub 2016 Nov 3. A Systematic Review and Meta-Analysis of Nutritional Supplementation in Chronic Lower Extremity Wounds. Ye J(1)(2), Mani R(2)(3)(4). Author information: (1)1 Ruijin Hospital, Shanghai, China. (2)2 Shanghai Jiao Tong University, Shanghai, China. (3)3 University of Southampton, Southampton, UK. (4)4 Chiang Mai University, Chiang Mai, Thailand. A systematic review and meta-analyses of nutritional supplementation to treat chronic lower extremity wounds was done in order to test the premise that impaired nutrition is implicated in healing. The databases of Ovid MEDLINE, Ovid EMBASE, Cochrane Library, and EBSCO CINAHL (1972-October 2014) were searched systematically. Only randomized controlled trials in adults with chronic lower extremity wounds were included. Both topical and systemic routes of supplementing nutrition were considered. The primary outcome was wound healing. Study characteristics, outcomes, and risk of bias were extracted by trained researchers and confirmed by the principal investigator. Twenty-three of 278 (8.3%) retrieved articles met the inclusion criteria and were selected. Most of the studies were of unclear or low risk. Overall, nutritional supplementation was favorable (risk ratio [RR] = 1.44, 95% confidence interval [CI] = 1.25-1.66). The systemic route was marginally better than the topical one (RR = 1.51, 95% CI = 1.36-1.67; RR = 1.14, 95% CI = 0.96-1.36, respectively). For venous ulcers, the data showed nutritional supplementation to be significantly beneficial compared to placebo (RR = 1.44, 95% CI = 1.31-1.59). Similar data were found for diabetic foot and sickle cell ulcers (RR = 1.17, 95% CI = 0.93-1.47; RR = 1.56, 95% CI = 0.94-2.60, respectively). These data permit the inferences that nutritional supplementation in the populations studied showed significant benefits in the healing of venous ulcers and tendency (nonsignificant trends) in the healing of diabetic and sickle cell ulcers. DOI: 10.1177/1534734616674624 PMID: 27810941 [Indexed for MEDLINE]
Appears in following Topics:
Diabetic Foot Ulcer - Treatment