Boyko EJ, Ahroni JH, Stensel VL, Smith DG, Davignon DR, Pecoraro RE, et al.
Diabetic medicine : a journal of the British Diabetic Association. Date of publication 1996 Jun 1;volume 13(6):549-54.
1. Diabet Med. 1996 Jun;13(6):549-54.
Predictors of transcutaneous oxygen tension in the lower limbs of diabetic
subjects.
Boyko EJ(1), Ahroni JH, Stensel VL, Smith DG, Davignon DR, Pecoraro RE.
Author information:
(1)Medical Service, Veterans Affairs Medical Centre, Seattle, Washington 98108,
USA.
We examined neuropathy, ankle pressure index (API), and other factors as
predictors of transcutaneous oxygen (TcPO2) in the lower limbs of 657 diabetic
subjects. Eligible subjects underwent a clinical assessment that included three
standard measures of autonomic neuropathy. TcPO2 measurements were performed at
37 degrees C and 44 degrees C at four lower limb locations. Associations between
potential predictors and TcPO2 were tested using univariate and multivariate
statistics. Mean TcPO2 at any site did not differ by presence of autonomic
neuropathy at either temperature, except for a significantly lower value at 44
degrees C below the knee (56.5 versus 59.2 mmHg, p = 0.021). In multivariate
analysis, autonomic neuropathy was significantly and independently related to leg
44 degrees C TcPO2 only (coefficient = -2.6734, p = 0.0182). Much stronger
associations were seen between TcPO2 and age, ankle blood pressure, and relative
body weight on the plantar foot; and between API, glycosylated haemoglobin, ankle
blood pressure, and pedal oedema on the dorsal foot and leg. We conclude that
factors related to lower limb TcPO2 vary depending on measurement site. Autonomic
neuropathy is not an important determinant of TcPO2 in the feet of diabetic
subjects. Although several predictors of TcPO2 were identified, most of the
variance of this measurement remains unexplained.
DOI: 10.1002/(SICI)1096-9136(199606)13:6<549::AID-DIA126>3.0.CO;2-R
PMID: 8799659 [Indexed for MEDLINE]
