Mohd Hilmi AB, Halim AS, Jaafar H, Asiah AB, Hassan A, et al.
BioMed research international. Date of publication 2013 Jan 1;volume 2013():795458.
1. Biomed Res Int. 2013;2013:795458. doi: 10.1155/2013/795458. Epub 2013 Nov 13.
Chitosan dermal substitute and chitosan skin substitute contribute to accelerated
full-thickness wound healing in irradiated rats.
Mohd Hilmi AB(1), Halim AS, Jaafar H, Asiah AB, Hassan A.
Author information:
(1)Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains
Malaysia, 16150 Kelantan, Malaysia.
Wounds with full-thickness skin loss are commonly managed by skin grafting. In
the absence of a graft, reepithelialization is imperfect and leads to increased
scar formation. Biomaterials can alter wound healing so that it produces more
regenerative tissue and fewer scars. This current study use the new chitosan
based biomaterial in full-thickness wound with impaired healing on rat model.
Wounds were evaluated after being treated with a chitosan dermal substitute, a
chitosan skin substitute, or duoderm CGF. Wounds treated with the chitosan skin
substitute showed the most re-epithelialization (33.2 ± 2.8%), longest epithelial
tongue (1.62 ± 0.13 mm), and shortest migratory tongue distance (7.11 ± 0.25 mm).
The scar size of wounds treated with the chitosan dermal substitute (0.13 ±
0.02 cm) and chitosan skin substitute (0.16 ± 0.05 cm) were significantly
decreased (P < 0.05) compared with duoderm (0.45 ± 0.11 cm). Human leukocyte
antigen (HLA) expression on days 7, 14, and 21 revealed the presence of human
hair follicle stem cells and fibroblasts that were incorporated into and
surviving in the irradiated wound. We have proven that a chitosan dermal
substitute and chitosan skin substitute are suitable for wound healing in
full-thickness wounds that are impaired due to radiation.
DOI: 10.1155/2013/795458
PMCID: PMC3845726
PMID: 24324974 [Indexed for MEDLINE]
