Niazi TM, Vuong T, Azoulay L, Marijnen C, Bujko K, Nasr E, Lambert C, Duclos M, Faria S, David M, Cummings B, et al.
International journal of radiation oncology, biology, physics. Date of publication 2012 Nov 1;volume 84(3):e305-10.
1. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):e305-10. doi:
10.1016/j.ijrobp.2012.03.062. Epub 2012 May 30.
Silver clear nylon dressing is effective in preventing radiation-induced
dermatitis in patients with lower gastrointestinal cancer: results from a phase
III study.
Niazi TM(1), Vuong T, Azoulay L, Marijnen C, Bujko K, Nasr E, Lambert C, Duclos
M, Faria S, David M, Cummings B.
Author information:
(1)Segal Cancer Centre, Department of Radiation Oncology, Jewish General
Hospital, McGill University, Canada.
PURPOSE: For patients with anal canal and advanced rectal cancer, chemoradiation
therapy is a curative modality or an important adjunct to surgery. Nearly all
patients treated with chemoradiation experience some degree of radiation-induced
dermatitis (RID). Prevention and effective treatment of RID, therefore, is of
considerable clinical relevance. The present phase III randomized trial compared
the efficacy of silver clear nylon dressing (SCND) with that of standard skin
care for these patients.
METHODS AND MATERIALS: A total of 42 rectal or anal canal cancer patients were
randomized to either a SCND or standard skin care group. SCND was applied from
Day 1 of radiation therapy (RT) until 2 weeks after treatment completion. In the
control arm, sulfadiazine cream was applied at the time of skin dermatitis.
Printed digital photographs taken 2 weeks prior to, on the last day, and two
weeks after the treatment completion were scored by 10 blinded readers, who used
the common toxicity scoring system for skin dermatitis.
RESULTS: The radiation dose ranged from 50.4 to 59.4 Gy, and there were no
differences between the 2 groups. On the last day of RT, when the most severe RID
occurs, the mean dermatitis score was 2.53 (standard deviation [SD], 1.17) for
the standard and 1.67 (SD, 1.2; P=.01) for the SCND arm. At 2 weeks after RT, the
difference was 0.39 points in favor of SCND (P=.39). There was considerable
intraclass correlation among the 10 observers.
CONCLUSIONS: Silver clear nylon dressing is effective in reducing RID in patients
with lower gastrointestinal cancer treated with combined chemotherapy and
radiation treatment.
Copyright © 2012 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.ijrobp.2012.03.062
PMID: 22652101 [Indexed for MEDLINE]
