Fernández-Castro M, Martín-Gil B, et al.
Enfermeria clinica. Date of publication 2015 Nov 1;volume 25(6):327-43.
1. Enferm Clin. 2015 Nov-Dec;25(6):327-43. doi: 10.1016/j.enfcli.2015.06.003. Epub
2015 Oct 21.
[Efectiveness of topical therapies in patients with breast cancer that experience
radiodermatitis. A systematic review].
[Article in Spanish]
Fernández-Castro M(1), Martín-Gil B(2).
Author information:
(1)Servicio de Oncología Radioterápica, Hospital Clínico Universitario de
Valladolid., Valladolid, España. Electronic address:
mefernandezc@saludcastillayleon.es.
(2)Servicio de Oncología Radioterápica, Hospital Clínico Universitario de
Valladolid., Valladolid, España.
BACKGROUND: After radiation therapy most patients experience acute skin toxicity
to some degree. The purpose of this systematic review is to assess the available
evidence concerning the effectivity of topical therapies on patients with breast
cancer that experience radiodermatitis after radiotherapy.
METHOD: The review included clinical trials aimed to evaluate topical therapies
for prevention or treatment of acute radiodermatitis in women with breast cancer,
which were published between 2009 and 2014. The bibliographic search was carried
out in the following databases: PubMed, Cinahl, Cochrane Plus, IBECS and LILACS.
The studies were selected independently by peer reviewers using the Critical
Appraisal Skills Programme in its Spanish version.
RESULTS: 86 bibliographical references were identified. Twenty full-text articles
of clinical trials were assessed and two were excluded because they were not
completed; 12 of clinical trials evaluated topical treatment with creams and
ointments, three with corticosteroid creams and other three with dressings. The
effectivity of human epidermal growth factor cream, linoleic acid emulsion,
topical silver sulfadiazine, corticosteroids creams and polyurethane dressings
has been shown in these clinical trials.
CONCLUSIONS: Given that radiodermatitis is a dynamic process, these topical
agents were effective in different stages of skin toxicity. Some of them delayed
the onset, others decreased the development and severity of acute skin toxicity
degree and others improved the subjective symptoms (itching, pain, burning). Only
polyurethane dressings suggest effectiveness in all stages of skin toxicity, in
prevention, management of the different skin toxicity degrees and improvement of
wellbeing.
Copyright © 2015. Published by Elsevier España, S.L.U.
DOI: 10.1016/j.enfcli.2015.06.003
PMID: 26475084 [Indexed for MEDLINE]
