Ng WL, Huang Q, Liu X, Zimmerman M, Li F, Li CY, et al.
Translational cancer research. Date of publication 2013 Oct 1;volume 2(5):442-448.
1. Transl Cancer Res. 2013 Oct 1;2(5):442-448.
Molecular mechanisms involved in tumor repopulation after radiotherapy.
Ng WL(1), Huang Q(1), Liu X(1), Zimmerman M(1), Li F(1), Li CY(1).
Author information:
(1)Department of Dermatology, Duke University Medical Center, Durham, NC 27710,
USA.
Radiotherapy remains one of most important treatment modalities for solid tumors.
Current radiotherapy is mostly based on a set of concepts called the 4"R"s, which
were established when there was lack of understanding of the underlying molecular
mechanisms. However, progress made in the past two decades are beginning to allow
us to see some of the molecular details involved in tumor response to radiation
therapy. In this review, we will attempt to summarize some of the key discoveries
in molecular radiation biology that have direct relevance to radiotherapy. We
will focus our discussion on areas such as radiation induced tumor
vasculogenesis, stem cell mobilization, and cellular repopulation. We hope our
discussion will stimulate further studies in this important area of cancer
research.
DOI: 10.3978/j.issn.2218-676X.2013.10.03
PMCID: PMC4293635
PMID: 25599021
