Akita S, Yoshimoto H, Ohtsuru A, Hirano A, Yamashita S, et al.
Radiation protection dosimetry. Date of publication 2012 Oct 1;volume 151(4):656-60.
1. Radiat Prot Dosimetry. 2012 Oct;151(4):656-60. Epub 2012 Aug 22.
Autologous adipose-derived regenerative cells are effective for chronic
intractable radiation injuries.
Akita S(1), Yoshimoto H, Ohtsuru A, Hirano A, Yamashita S.
Author information:
(1)Division of Plastic and Reconstructive Surgery, Department of Developmental
and Reconstructive Medicine, Nagasaki University, Graduate School of Biomedical
and Sciences, Nagasaki, Japan. akitas@hf.rim.or.jp
Effective therapy for chronic radiation injuries, such as ulcers, is prone to
infection. Stiffness is expected since the therapeutic radiation often involves
wider and deeper tissues and often requires extensive debridement and
reconstruction, which are not sometimes appropriate for elderly and compromised
hosts. Autologous adipose-derived regenerative cells (ADRCs) are highly yielding,
forming relatively elderly aged consecutive 10 cases, 63.6±14.9 y (52-89 y), with
mean radiation dose of 75.0±35.4 Gy (50-120 Gy) were included with at least
10-month follow-up. Minimal debridement and ADRC injection in the wound bed and
margin along with the injection of mixture of fat and ADRCs in the periphery were
tested for efficacy and regenerated tissue quality by clinically as well as
imaging by computed tomography and magnetic resonance imaging. Uncultured ADRCs
of 1.6±1.3×10(7) cells were obtained. All cases healed uneventfully after 6.6±3.2
weeks (2-10 weeks) post-operatively. The done site morbidity was negligible and
without major complications, such as paralysis or massive haematoma. The
regenerated tissue quality was significantly superior to the pre-operative one
and the mixture of fat and ADRCs connected to the intact tissue was very soft and
pliable. Mean follow-up at 1.9±0.8 y (0.9-2.9 y) revealed no recurrence or new
ulceration after treatment. Thus, the ADRCs treatment for decades-long radiation
injuries is effective, safe and improves the quality of wounds.
DOI: 10.1093/rpd/ncs176
PMID: 22914335 [Indexed for MEDLINE]
