Bey E, Prat M, Duhamel P, Benderitter M, Brachet M, Trompier F, Battaglini P, Ernou I, Boutin L, Gourven M, Tissedre F, Créa S, Mansour CA, de Revel T, Carsin H, Gourmelon P, Lataillade JJ, et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the Eur.... Date of publication 2010 Jan 1;volume 18(1):50-8.
1. Wound Repair Regen. 2010 Jan-Feb;18(1):50-8. doi:
10.1111/j.1524-475X.2009.00562.x.
Emerging therapy for improving wound repair of severe radiation burns using local
bone marrow-derived stem cell administrations.
Bey E(1), Prat M, Duhamel P, Benderitter M, Brachet M, Trompier F, Battaglini P,
Ernou I, Boutin L, Gourven M, Tissedre F, Créa S, Mansour CA, de Revel T, Carsin
H, Gourmelon P, Lataillade JJ.
Author information:
(1)Hôpital d'Instruction des Armées Percy, Service de Chirurgie Plastique, BP
410, 92141 Clamart Cedex, France.
The therapeutic management of severe radiation burns remains a challenging issue
today. Conventional surgical treatment including excision, skin autograft, or
flap often fails to prevent unpredictable and uncontrolled extension of the
radiation-induced necrotic process. In a recent very severe accidental radiation
burn, we demonstrated the efficiency of a new therapeutic approach combining
surgery and local cellular therapy using autologous mesenchymal stem cells (MSC),
and we confirmed the crucial place of the dose assessment in this medical
management. The patient presented a very significant radiation lesion located on
the arm, which was first treated by several surgical procedures: iterative
excisions, skin graft, latissimus muscle dorsi flap, and forearm radial flap.
This conventional surgical therapy was unfortunately inefficient, leading to the
use of an innovative cell therapy strategy. Autologous MSC were obtained from
three bone marrow collections and were expanded according to a clinical-grade
protocol using platelet-derived growth factors. A total of five local MSC
administrations were performed in combination with skin autograft. After
iterative local MSC administrations, the clinical evolution was favorable and no
recurrence of radiation inflammatory waves occurred during the patient's 8-month
follow-up. The benefit of this local cell therapy could be linked to the "drug
cell" activity of MSC by modulating the radiation inflammatory processes, as
suggested by the decrease in the C-reactive protein level observed after each MSC
administration. The success of this combined treatment leads to new prospects in
the medical management of severe radiation burns and more widely in the
improvement of wound repair.
DOI: 10.1111/j.1524-475X.2009.00562.x
PMID: 20082681 [Indexed for MEDLINE]
