Delanian S, Baillet F, Huart J, Lefaix JL, Maulard C, Housset M, et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncol.... Date of publication 1994 Jul 1;volume 32(1):12-20.
1. Radiother Oncol. 1994 Jul;32(1):12-20.
Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn
superoxide dismutase: clinical trial.
Delanian S(1), Baillet F, Huart J, Lefaix JL, Maulard C, Housset M.
Author information:
(1)Department of Radiation Therapy, Necker Hospital, Université Paris V, France.
Based on experimental and clinical evidence indicating that the anti-oxidant
agent liposomal Cu/Zn superoxide dismutase (Lipsod) is an effective
anti-inflammatory drug and possibly might be effective in reducing late
radiation-induced tissue injury, a clinical trial using Lipsod to treat
long-standing radiation-induced fibrosis (RIF) was begun at the Necker Hospital,
Paris in May 1984. Thirty-four patients presenting 42 distinct palpable zones of
RIF involving the skin and underlying tissues were treated from May 1984 to
January 1986 and followed for an average of 5 years (range, 14-89 months). Lipsod
was administered over 3 weeks in twice weekly i.m. injections of 5 mg for a total
of 30 mg. Patients underwent two physical examinations by independent physicians
at each check-up. Parameters noted included determination of the density of the
palpated fibrotic block and the dimensions of the projected cutaneous surface.
The extent of change in the fibrotic zone was expressed as the ratio of the sum
of the dimensions (L + W) and the ratio of the uncorrected areas (L x W) of the
projected cutaneous surface before and after treatment. Changes in density were
noted and scored. All patients showed some clinical regression of fibrosis. In
most patients, clinically assessable regression begun during the third week of
treatment and was maximum by 2 months. The mean decreases in the linear
dimensions (L + W) and in the area (L x W) of the projected cutaneous surface
were 41 +/- 30% and 57 +/- 26%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID: 7938674 [Indexed for MEDLINE]
