Hemati S, Asnaashari O, Sarvizadeh M, Motlagh BN, Akbari M, Tajvidi M, Gookizadeh A, et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Car.... Date of publication 2012 Aug 1;volume 20(8):1613-8.
1. Support Care Cancer. 2012 Aug;20(8):1613-8. doi: 10.1007/s00520-011-1250-5. Epub
2011 Oct 19.
Topical silver sulfadiazine for the prevention of acute dermatitis during
irradiation for breast cancer.
Hemati S(1), Asnaashari O, Sarvizadeh M, Motlagh BN, Akbari M, Tajvidi M,
Gookizadeh A.
Author information:
(1)Department of Radiation Oncology, Seyed Al-Shohada Hospital, Isfahan
University of Medical Sciences, Shiri Bridge, Isfahan, Iran.
hematti@med.mui.ac.ir
PURPOSE: This study aimed to evaluate the effectiveness of topical silver
sulfadiazine (SSD) in preventing acute radiation dermatitis in women receiving
radiotherapy for breast cancer.
METHODS: A randomized controlled clinical trial was conducted on patients with
breast cancer referred for radiotherapy after treatment with mastectomy and
chemotherapy. The patients were randomized into the intervention (n = 51) and
control (n = 51) groups and were instructed on general skin care during
radiotherapy. The intervention group received SSD cream 1%, three times a day, 3
days a week, for 5 weeks during radiotherapy and one week thereafter. A blinded
observer assessed the severity of dermatitis weekly (for 6 weeks) and graded it
from 0 to 4 according to the Radiation Therapy Oncology Group criteria.
RESULTS: The two groups were similar in baseline characteristics. Two patients in
the control group discontinued the radiotherapy course because of severe skin
injuries (grades 3 and 4). The intervention group encountered significantly less
severe dermatitis during radiotherapy compared to the controls. The total score
of skin injury was also lower in the intervention group compared with controls
(5.49 ± 1.02 vs. 7.21 ± 1.76, p < 0.001). A multivariate analysis found that the
use of SSD cream (p < 0.001) and flat chest wall anatomy (p = 0.008) were
significantly associated with a decreased skin injury.
CONCLUSIONS: SSD cream reduced the severity of radiation-induced skin injury
compared with general skin care alone. Further studies in patients with other
types of cancer and also comparing SSD cream with other topical agents are
warranted.
DOI: 10.1007/s00520-011-1250-5
PMID: 22006502 [Indexed for MEDLINE]
