Zenda S, Ota Y, Tachibana H, Ogawa H, Ishii S, Hashiguchi C, Akimoto T, Ohe Y, Uchitomi Y, et al.
Journal of radiation research. Date of publication 2016 Jun 1;volume 57(3):301-6.
1. J Radiat Res. 2016 Jun;57(3):301-6. doi: 10.1093/jrr/rrv092. Epub 2016 Feb 4.
A prospective picture collection study for a grading atlas of radiation
dermatitis for clinical trials in head-and-neck cancer patients.
Zenda S(1), Ota Y(2), Tachibana H(3), Ogawa H(4), Ishii S(5), Hashiguchi C(6),
Akimoto T(5), Ohe Y(7), Uchitomi Y(8).
Author information:
(1)Department of Radiation Oncology, National Cancer Center Hospital East, 6-5-1
Kashiwanoha, Kashiwa, Chiba 277-8577, Japan Innovation Center for Supportive,
Palliative and Psychosocial Care, National Cancer Center Hospital
szenda@east.ncc.go.jp.
(2)Department of radiation Oncology, Hyogo Cancer Center.
(3)Division of Radiation Oncology, Aichi Cancer Center Hospital.
(4)Division of Radiation Oncology, Shizuoka Cancer Center Hospital.
(5)Department of Radiation Oncology, National Cancer Center Hospital East, 6-5-1
Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
(6)Nursing Hyogo Cancer Center.
(7)Department of Thoracic Oncology, National Cancer Center Hospital.
(8)Innovation Center for Supportive, Palliative and Psychosocial Care, National
Cancer Center Hospital.
Radiation dermatitis is one of the most common acute toxicities of both
radiotherapy and chemoradiotherapy. Many clinical trials have evaluated the level
of toxicity using the Common Terminology Criteria for Adverse Events ver. 4.03.
This criterion accounts for severity in a single sentence only, and no visual
classification guide has been available. Thus, there is a risk of subjective
interpretation by the individual investigator. This contrasts with the situation
with hematologic toxicities, which can be interpreted objectively. The aim of
this prospective picture collection study was to develop a grading tool for use
in establishing the severity of radiation dermatitis in clinical trials. A total
of 118 patients who were scheduled to receive definitive or postoperative
radiotherapy or chemoradiotherapy were enrolled from the four participating
cancer centers. All researchers in our group used the same model of camera under
the same shooting conditions to maintain consistent photographic quality. In all,
1600 photographs were collected. Of these, 100 photographs qualified for the
first round of selection and were then graded by six experts, basically in
accordance with the CTCAE ver. 4.03 (JCOG ver. in Japanese). After further study,
38 photographs were selected as representing typical models for Grade 1-4
radiation dermatitis; the radiation dermatitis grading atlas was produced from
these photographs. The atlas will play a major role in ensuring that the
dermatitis rating system is consistent between the institutions participating in
trials. We hope that this will contribute to improving the quality of clinical
trials, and also to improving the level of routine clinical practice.
© The Author 2016. Published by Oxford University Press on behalf of The Japan
Radiation Research Society and Japanese Society for Radiation Oncology.
DOI: 10.1093/jrr/rrv092
PMCID: PMC4915537
PMID: 26850926 [Indexed for MEDLINE]
