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Barnett GC, West CM, Dunning AM, Elliott RM, Coles CE, Pharoah PD, Burnet NG, et al.
Nature reviews. Cancer. Date of publication 2009 Feb 1;volume 9(2):134-42.
1. Nat Rev Cancer. 2009 Feb;9(2):134-42. doi: 10.1038/nrc2587. Epub 2009 Jan 16. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Barnett GC(1), West CM, Dunning AM, Elliott RM, Coles CE, Pharoah PD, Burnet NG. Author information: (1)Department of Oncology, University of Cambridge, Oncology Centre, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. gillbarnett@doctors.org.uk A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. DOI: 10.1038/nrc2587 PMCID: PMC2670578 PMID: 19148183 [Indexed for MEDLINE]
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Radiation-induced Cutaneous Damage - Introduction and Assessment