Aitasalo K, Aro H, et al.
Plastic and reconstructive surgery. Date of publication 1986 Feb 1;volume 77(2):256-67.
1. Plast Reconstr Surg. 1986 Feb;77(2):256-67.
Irradiation-induced hypoxia in bones and soft tissues: an experimental study.
Aitasalo K, Aro H.
Bone marrow and subcutaneous tissue pO2 and pCO2 were measured by means of
implanted tissue tonometers in irradiated and nonirradiated rabbit hind limbs.
The x-ray dose was 500, 1000, 1500, 2000, and 3000 rads. Tissue gas tensions were
measured 1 day and 5 and 11 weeks after radiation. The pCO2 changes in both
tissues were slight but not statistically significant. The subcutaneous tissue
pO2 decreased during the acute phase of irradiation injury, and the effect of
irradiation was dose-dependent. Later on, irradiation had no significant effects
on the subcutaneous pO2, although light microscopy of the affected tissues showed
fibrosis and blood vessel changes. The response of the subcutaneous pO2 to
systemic hyperoxia also increased in the chronic phase of irradiation injury as a
sign of improved microcirculation. The bone marrow showed a high
radiosensitivity. Irradiation caused a rapid dose-dependent decrease of the
marrow pO2, and the marrow pO2 decreased with time during the chronic phase of
irradiation injury. The marrow pO2 responded slowly and marginally to an
increment of arterial pO2 during breathing 100% oxygen as further evidence of
impaired vascular pattern. The results showed that irradiation causes only a
transient impairment of tissue perfusion in the skin. However,
irradiation-damaged marrow was characterized by progressive tissue hypoxia.
PMID: 3080764 [Indexed for MEDLINE]
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