Author(s) Herskind C, Bamberg M, Rodemann HP, et al.

Journal Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. Date of publication 1998 Nov 1;volume 174 Suppl 3():12-5.

Abstract 1. Strahlenther Onkol. 1998 Nov;174 Suppl 3:12-5. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Herskind C(1), Bamberg M, Rodemann HP. Author information: (1)Department of Radiotherapy, University of Tübingen. carsten.herskind@uni-tuebingen.de BACKGROUND: Cytokines are important for signaling between cells and tissues and constitute a humoral component of the response of cells and tissues to radiotherapy. Although several cytokines have been implicated in mediating radiation-induced reactions of normal tissues, the mechanisms are only beginning to be elucidated. METHODS: Published data on radiation-induced cytokine expression from cell culture, experimental and clinical studies are reviewed. Current models of cytokine-mediated multicellular interactions in radiation-induced reactions of the lung, skin and intestinal mucosa are presented. RESULTS AND CONCLUSION: The major cytokines in the radiation response of non-hemopoietic tissues include IL-6, IL-1, INF alpha and TGF beta. Different cell types interact via cytokines in a complex network of effector and receptor cells, including inflammatory cells, tissue-specific functional cells and fibroblasts. TGF beta appears to be of particular importance in the development of late reactions such as fibrosis. PMID: 9830449 [Indexed for MEDLINE]

Source ID (e.g. PMID): 9830449