Gu Q, Wang D, Cui C, Gao Y, Xia G, Cui X, et al.
Journal of environmental pathology, toxicology and oncology : official organ of the Internation.... Date of publication 1998 Jan 1;volume 17(2):117-23.
1. J Environ Pathol Toxicol Oncol. 1998;17(2):117-23.
Effects of radiation on wound healing.
Gu Q(1), Wang D, Cui C, Gao Y, Xia G, Cui X.
Author information:
(1)Institute of Radiation Medicine, Beijing, PR China.
The pathological changes of radiation on wound healing in rats were observed by
macroscopic, microscopic, and electronmicroscopic examination and detection of
collagen types. We found that the wound healing process was obviously delayed by
irradiation. First, the early phase inflammatory response was severely inhibited.
In particular, the number of infiltrating macrophages and neutrophils was
decreased, blood vessels were injured, and hemorrhage was evident. Second, the
formation and maturation of granulation tissue were slowed down, fibroblasts were
injured, and transcription of types and collagen mRNAs and synthesis and
secretion of collagen were reduced. Finally, the reepithelialization process was
delayed and the healing time was prolonged.
PMID: 9546747 [Indexed for MEDLINE]
