Housri N, Yarchoan R, Kaushal A, et al.
Cancer. Date of publication 2010 Jan 15;volume 116(2):273-83.
1. Cancer. 2010 Jan 15;116(2):273-83. doi: 10.1002/cncr.24878.
Radiotherapy for patients with the human immunodeficiency virus: are special
precautions necessary?
Housri N(1), Yarchoan R, Kaushal A.
Author information:
(1)Radiation Oncology Branch, Center for Cancer Research, National Cancer
Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Shortly after the onset of the acquired immunodeficiency syndrome (AIDS) epidemic
in the 1980s, reports of radiation-associated toxicity in patients with the human
immunodeficiency virus (HIV) and AIDS began to appear in the medical literature.
Although the majority of reports have focused on AIDS-defining malignancies such
as Kaposi sarcoma, greater-than-expected toxicity after a course of radiotherapy
or chemoradiotherapy has also been documented in cancers not generally classified
as being related to HIV. With improved antiretroviral therapies, HIV patients are
living longer and have the potential to develop a variety of HIV-associated and
nonassociated malignancies that require treatment, including radiotherapy. This
review reports the published data regarding the interactions of HIV, AIDS, and
antiretroviral therapy with radiotherapy and implications for the management of
malignancies in patients with HIV.
DOI: 10.1002/cncr.24878
PMCID: PMC3409663
PMID: 20014399 [Indexed for MEDLINE]
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