Vuong T, Franco E, Lehnert S, Lambert C, Portelance L, Nasr E, Faria S, Hay J, Larsson S, Shenouda G, Souhami L, Wong F, Freeman C, et al.
International journal of radiation oncology, biology, physics. Date of publication 2004 Jul 1;volume 59(3):809-14.
1. Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):809-14.
Silver leaf nylon dressing to prevent radiation dermatitis in patients undergoing
chemotherapy and external beam radiotherapy to the perineum.
Vuong T(1), Franco E, Lehnert S, Lambert C, Portelance L, Nasr E, Faria S, Hay J,
Larsson S, Shenouda G, Souhami L, Wong F, Freeman C.
Author information:
(1)Department of Radiation Oncology, McGill University Health Centre, Montreal,
Quebec, Canada. te.vuong@muhc.mcgill.ca
PURPOSE: Silver-leaf nylon dressing (SLND) has been shown to have effective
antimicrobial activity and to enhance healing in burns and skin grafts. The
purpose of this study was to evaluate the value of SLND in preventing radiation
dermatitis in patients undergoing radiotherapy to target volumes that included
the perineum and concurrent chemotherapy.
METHODS AND MATERIALS: Fifteen consecutive patients with either anal canal or
gynecologic cancer were offered the SLND as a preventive intervention. The
evaluation was based on standardized photographs taken at the end of treatment. A
historical control group of 15 patients with the same neoplasms who received
standard skin care was assessed in the same fashion. Ten observers unaware of the
treatment intervention were enrolled in the evaluation of the skin changes. The
Mann-Whitney U test was used to assess the statistical significance of the
differences in the dermatitis scores between the two patient groups.
RESULTS: The mean dermatitis score for controls was 2.62 (standard deviation,
0.48). The mean score for the SLND group was significantly lower at 1.16
(standard deviation, 0.40; p <0.0001).
CONCLUSION: The results of this study suggest that SLND is effective in reducing
radiation dermatitis, apparently because of its antibacterial properties.
DOI: 10.1016/j.ijrobp.2003.11.031
PMID: 15183484 [Indexed for MEDLINE]
