Gieringer M, Gosepath J, Naim R, et al.
Oncology reports. Date of publication 2011 Aug 1;volume 26(2):299-307.
1. Oncol Rep. 2011 Aug;26(2):299-307. doi: 10.3892/or.2011.1319. Epub 2011 May 25.
Radiotherapy and wound healing: principles, management and prospects (review).
Gieringer M(1), Gosepath J, Naim R.
Author information:
(1)Dr. Horst Schmidt Klinik, Ludwig-Erhard Str. 100, D-65199 Wiesbaden, Germany.
mkgieringer@gmail.com
Radiation therapy is a major therapeutic modality in the management of cancer
patients. Over 60% of these patients receive radiotherapy at some point during
their course of treatment and over 90% will develop skin reactions after therapy.
Problematic wound healing in radiation-damaged tissue constitutes a major
surgical difficulty and despite all efforts, irradiated skin remains a
therapeutic challenge. This review provides an overview of the fundamental
principles of radiation therapy with regards to the wound healing in normal and
irradiated skin. Furthermore, it presents techniques that describe how to prevent
and manage skin side effects as well as prospects that may improve cutaneous
wound repair in general and in irradiated skin.
DOI: 10.3892/or.2011.1319
PMID: 21617873 [Indexed for MEDLINE]
Appears in following Topics:
